Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 366465..367108 Replicon chromosome
Accession NZ_CP069063
Organism Mycobacterium tuberculosis strain N3913

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag JN150_RS01605 Protein ID WP_003401566.1
Coordinates 366683..367108 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag JN150_RS01600 Protein ID WP_003401563.1
Coordinates 366465..366686 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN150_RS01575 361539..362342 - 804 WP_003401540.1 Stf0 family sulphotransferase -
JN150_RS01580 362352..363749 - 1398 WP_003401544.1 sulfatase -
JN150_RS01585 363928..365748 + 1821 WP_003401546.1 PE family protein -
JN150_RS01590 365891..366118 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
JN150_RS01595 366115..366417 + 303 WP_003401560.1 toxin-antitoxin system toxin -
JN150_RS01600 366465..366686 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
JN150_RS01605 366683..367108 + 426 WP_003401566.1 PIN domain nuclease Toxin
JN150_RS01610 367243..367875 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
JN150_RS01615 367872..368780 + 909 WP_003900117.1 protochlorophyllide reductase -
JN150_RS01620 368788..369378 - 591 WP_229298012.1 hypothetical protein -
JN150_RS01625 369371..369421 - 51 Protein_321 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T188924 WP_003401566.1 NZ_CP069063:366683-367108 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T188924 NZ_CP090593:1799908-1800228 [Pectobacterium aroidearum]
ATGCAAACATCACCTGCAATCCCGCCACGGGAGGATAACCCCTGTGCGTCACCTGTAGCCGTCTGGCAACAACTGCTGAC
CTACCTGCTGGAAAAGCACTACGGCCTGACGCTGAACGACACACCGTTCTGTGAGGAAAATGTCATTCAGGCGCATATCG
ATGCTGGCGTCACGCTGGTCAATGCCGTGAACTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGCTCGCGACGGTTTT
AACTGGCAGGAGCAATCGCCGTTTCTTACCGCTGTTGATATTCTCCGTGCCAGACGTGCTACCGGCTTGCTCAAGGCATA
A

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT188924 WP_003401563.1 NZ_CP069063:366465-366686 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT188924 NZ_CP090593:1799503-1799838 [Pectobacterium aroidearum]
ATGCCATCATCGGATACCCCGGAGTGGGGATTAAAATGTGCCATCACTCGGCGATTCGGAGCCAGACTGGTGCAGGAAGG
TAACCGTCTGCACTATCTGGCAGACCGGGCCAGCATTGTCGGTACGTTTAGCAAAACAGAAGCCCAAAGTCTGGAGCGTT
GTTTCCCTGAGCTAATTGAGCTGTTGGAACAGAAGCTACGCATGGGGGAACTGAATCCCCGTCAGCAGGGGGGTGTCACG
TTGTATTGTAACGAATGGACCTGTGAAGCCGATACGCTGGGCAGTGTTGGCTACGTGTATATTGTTATTTATCCTTCTTC
AGCGGCAACACAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References