Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3804737..3805404 Replicon chromosome
Accession NZ_CP069062
Organism Mycobacterium tuberculosis strain N0069

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag JN151_RS17825 Protein ID WP_003417916.1
Coordinates 3804737..3805129 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag JN151_RS17830 Protein ID WP_003912214.1
Coordinates 3805129..3805404 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN151_RS17810 3800107..3801945 - 1839 WP_019830554.1 1-deoxy-D-xylulose-5-phosphate synthase -
JN151_RS17815 3801942..3802931 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
JN151_RS17820 3802931..3803983 - 1053 WP_003900678.1 polyprenyl synthetase family protein -
JN151_RS17825 3804737..3805129 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
JN151_RS17830 3805129..3805404 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JN151_RS17835 3805586..3806957 + 1372 Protein_3525 ISNCY family transposase -
JN151_RS17840 3807147..3809399 + 2253 WP_031663852.1 PE family protein -
JN151_RS17845 3809470..3810342 - 873 WP_003417929.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3806280..3806957 677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T188919 WP_003417916.1 NZ_CP069062:c3805129-3804737 [Mycobacterium tuberculosis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

>T188919 NZ_CP090592:c3067652-3067332 [Pectobacterium aroidearum]
ATGCAAGCAACACCAGCAATCCCGTCAGGGGAGGATAACCCCTGTCCGTCACCCATAGCCGCCTGGCAGCAACTGTTGAC
CTACCTTATGGAAAAACACTACGGCCTGACACTGAACGACACGCCGTTCTGTGAGGAAAACGTGATTCAGGAACATATCG
ATGCTGGCATCACGTTGGTCAATGCCGTCAATTTTCTGGTGGAGAAATACGAACTGGTGCGTATCGATCGCAACGGCTTT
AACTGGCAGGAGCAATCGCCGTTTCTTACCGCCGTTGATGTTCTCCGTGCCAGACGTGCTACTGGCTTGCTCAAGACATA
A

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT188919 WP_003912214.1 NZ_CP069062:c3805404-3805129 [Mycobacterium tuberculosis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp

>AT188919 NZ_CP090592:c3068057-3067722 [Pectobacterium aroidearum]
ATGTCATCAGTAGAGGCCCCGGAATGGGGATTAAAGTGTGCTGTCACGCCGCGATTCGGAGCCAGGCTGGTCCAGGAAGG
ACACCGCCTGCATTATCTGGAAGACCGGGCCAGCATTGTCGGTACGTTCAGCAAAACAGAAGCCCGCAATCTGGAGCGTT
GCTTCCCTGAGCTGATTAAGCAGTTGGAGCAGAAACTACGAACGGGAGAACTGAACCCCTGTCAGCAAGGCTGCATCGTG
CTGCATTGCAACGAATGGACCTGTGAAGCCGATACGCTGGGCAGTTTTGGCTACGTGTATATTGCTATTTATCCCTCTTC
AGCGGCAACACAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References