Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 3138099..3138703 Replicon chromosome
Accession NZ_CP069062
Organism Mycobacterium tuberculosis strain N0069

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag JN151_RS14890 Protein ID WP_003414492.1
Coordinates 3138099..3138491 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A829CBY8
Locus tag JN151_RS14895 Protein ID WP_003414495.1
Coordinates 3138488..3138703 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN151_RS14860 3133249..3134037 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
JN151_RS14865 3134371..3134916 - 546 WP_003908074.1 DUF1802 family protein -
JN151_RS14870 3135188..3136072 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
JN151_RS14875 3136075..3136962 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
JN151_RS14880 3137267..3137812 - 546 WP_003908074.1 DUF1802 family protein -
JN151_RS14885 3137809..3138078 - 270 WP_003414489.1 DUF2277 family protein -
JN151_RS14890 3138099..3138491 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
JN151_RS14895 3138488..3138703 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JN151_RS14900 3138750..3139499 + 750 Protein_2941 enoyl-CoA hydratase -
JN151_RS14905 3139578..3140660 - 1083 WP_003414499.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -
JN151_RS14910 3140653..3141963 - 1311 WP_003414501.1 ABC transporter substrate-binding protein -
JN151_RS14915 3141966..3142793 - 828 WP_003414504.1 carbohydrate ABC transporter permease -
JN151_RS14920 3142790..3143701 - 912 WP_003414505.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T188913 WP_003414492.1 NZ_CP069062:c3138491-3138099 [Mycobacterium tuberculosis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T188913 NZ_CP090592:368942-369229 [Pectobacterium aroidearum]
ATGACCTATAAGTTAAAATTTGTGCCTTCTGCAATGAAGGAATGGAAAAAATTAGGGCATCCTGTCAGAGAACAATTCAA
AAAAAAGCTAGTTGAGCGTTTAGAAAATCCTCGTGTTCCTTCAGCCCAGCTCCATGGTCGTAAAGACCAGTATAAAATTA
AACTGAAGTCTGCTGGTTACAGGCTGGTGTATTTGGTTCAGGATGAGACCATTACGGTGATGGTCATGGGGGTTGGAAAG
CGCGAAGGTAGTCAGGTTTATTCTGATACTAAAGGTCGCTCTGCTTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7511.55 Da        Isoelectric Point: 4.9732

>AT188913 WP_003414495.1 NZ_CP069062:c3138703-3138488 [Mycobacterium tuberculosis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Download         Length: 216 bp

>AT188913 NZ_CP090592:368698-368952 [Pectobacterium aroidearum]
ATGGCTTTCAATATCCTAACTAACACAGCGGCCAGTATCACTGAACTGAAACGCGACCCAATGGGGACAGTACGGGCTGC
TGAAGGTGAGACTATCGCTATACTGAACCGGAATGAGCCTGCGTTCTATTGTGTGCCTCCTGCCATGTTCGCTTATTTAA
TGGAATTGGCTGAAGATGCAGAGTTGGGGCGTACTGTTGATGATCGTATGTCAGAGTTAGCTGACGCGGAAGAGATTTCG
CTCGATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBY8

References