Detailed information of TA system TA188908

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2938619..2939333
• Replicon: chromosome
• Accession: NZ_CP069062
• Organism: Mycobacterium tuberculosis strain N0069

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQK0
• Locus tag: JN151_RS13740
• Protein ID: WP_003413460.1
• Coordinates: 2938893..2939333 (+)
• Length: 147 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WJ20
• Locus tag: JN151_RS13735
• Protein ID: WP_003413456.1
• Coordinates: 2938619..2938906 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN151_RS13700	2934041..2934286	+	246	WP_031663784.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
JN151_RS13705	2934283..2934687	+	405	WP_003413432.1	type II toxin-antitoxin system VapC family toxin	-
JN151_RS13710	2934904..2935524	+	621	WP_003413441.1	DUF4178 domain-containing protein	-
JN151_RS13715	2935535..2936029	+	495	WP_003413444.1	DUF2617 family protein	-
JN151_RS13720	2936026..2936457	+	432	WP_003413445.1	DUF4247 domain-containing protein	-
JN151_RS13725	2936482..2936940	+	459	WP_003413451.1	DUF350 domain-containing protein	-
JN151_RS13730	2936937..2938508	+	1572	WP_003899392.1	polyamine aminopropyltransferase	-
JN151_RS13735	2938619..2938906	+	288	WP_003413456.1	antitoxin VapB41	Antitoxin
JN151_RS13740	2938893..2939333	+	441	WP_003413460.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN151_RS13745	2939354..2940109	-	756	WP_003413464.1	YebC/PmpR family DNA-binding transcriptional regulator	-
JN151_RS13750	2940242..2940838	-	597	WP_003413465.1	pyridoxal 5'-phosphate synthase glutaminase subunit PdxT	-
JN151_RS13755	2940846..2941691	-	846	WP_003413466.1	acyl-CoA thioesterase II	-
JN151_RS13760	2941720..2942619	-	900	WP_003413468.1	pyridoxal 5'-phosphate synthase lyase subunit PdxS	-
JN151_RS13765	2942747..2943421	+	675	WP_003413471.1	pyridoxamine 5'-phosphate oxidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-146)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 147 a.a.
• Molecular weight: 16026.38 Da
• Isoelectric Point: 6.8599

>T188908 WP_003413460.1 NZ_CP069062:2938893-2939333 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Nucleotide

• Length: 441 bp

>T188908 NZ_CP090591:c4435779-4435492 [Pectobacterium aroidearum]
ATGATCTATAAGTTAAAATTTGTGCCTTCTGCAATGAAGGAATGGAAAAAATTAGGGCATCCTGTCAGGGAACAATTCAA
AAAAAAGCTAGTTGAGCGTTTAGAAAATCCTCGTGTTCCTTCAGCCCAGCTTCATGGTCGTAAAGACCAGTATAAAATTA
AACTGAAGTCTGCTGGCTACAGACTGGTATATTTGGTTCAGGATGAGACCATTACGGTGATGGTCATGGGGGGTGGAAAG
CGCGAAGGTAGTCAGGTTTATTCTGATACTAAAGGTCGCTCTGCTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10453.98 Da
• Isoelectric Point: 7.2797

>AT188908 WP_003413456.1 NZ_CP069062:2938619-2938906 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Nucleotide

• Length: 288 bp

>AT188908 NZ_CP090591:c4436023-4435769 [Pectobacterium aroidearum]
ATGGCTTTCAATATCCTAACTAACACAGCGGCCAGCATCACTGAACTGAAACGCGACCCAATGGGGACAGTACGGGCTGC
TGAAGGTGAGACTATCGCTATACTGAACCGGAATGAGCCTGCGTTCTATTGTGTGCCTCCTGCCATGTTCGCTTATTTAA
TGGAATTGGCTGAAGATGCAGAGCTGGGGCGTACTGTTGATGATCGTATGTCAGAGTTAGCTGACGCGGAAGAGATTTCG
CTCGATGATCTATAA

Structures

Toxin

• AlphaFold DB: G0TQK0

Antitoxin

• AlphaFold DB: A0A7U4BWB8