Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2938619..2939333 Replicon chromosome
Accession NZ_CP069062
Organism Mycobacterium tuberculosis strain N0069

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag JN151_RS13740 Protein ID WP_003413460.1
Coordinates 2938893..2939333 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag JN151_RS13735 Protein ID WP_003413456.1
Coordinates 2938619..2938906 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN151_RS13700 2934041..2934286 + 246 WP_031663784.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
JN151_RS13705 2934283..2934687 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
JN151_RS13710 2934904..2935524 + 621 WP_003413441.1 DUF4178 domain-containing protein -
JN151_RS13715 2935535..2936029 + 495 WP_003413444.1 DUF2617 family protein -
JN151_RS13720 2936026..2936457 + 432 WP_003413445.1 DUF4247 domain-containing protein -
JN151_RS13725 2936482..2936940 + 459 WP_003413451.1 DUF350 domain-containing protein -
JN151_RS13730 2936937..2938508 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
JN151_RS13735 2938619..2938906 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
JN151_RS13740 2938893..2939333 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
JN151_RS13745 2939354..2940109 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
JN151_RS13750 2940242..2940838 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
JN151_RS13755 2940846..2941691 - 846 WP_003413466.1 acyl-CoA thioesterase II -
JN151_RS13760 2941720..2942619 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
JN151_RS13765 2942747..2943421 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T188908 WP_003413460.1 NZ_CP069062:2938893-2939333 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T188908 NZ_CP090591:c4435779-4435492 [Pectobacterium aroidearum]
ATGATCTATAAGTTAAAATTTGTGCCTTCTGCAATGAAGGAATGGAAAAAATTAGGGCATCCTGTCAGGGAACAATTCAA
AAAAAAGCTAGTTGAGCGTTTAGAAAATCCTCGTGTTCCTTCAGCCCAGCTTCATGGTCGTAAAGACCAGTATAAAATTA
AACTGAAGTCTGCTGGCTACAGACTGGTATATTTGGTTCAGGATGAGACCATTACGGTGATGGTCATGGGGGGTGGAAAG
CGCGAAGGTAGTCAGGTTTATTCTGATACTAAAGGTCGCTCTGCTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT188908 WP_003413456.1 NZ_CP069062:2938619-2938906 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT188908 NZ_CP090591:c4436023-4435769 [Pectobacterium aroidearum]
ATGGCTTTCAATATCCTAACTAACACAGCGGCCAGCATCACTGAACTGAAACGCGACCCAATGGGGACAGTACGGGCTGC
TGAAGGTGAGACTATCGCTATACTGAACCGGAATGAGCCTGCGTTCTATTGTGTGCCTCCTGCCATGTTCGCTTATTTAA
TGGAATTGGCTGAAGATGCAGAGCTGGGGCGTACTGTTGATGATCGTATGTCAGAGTTAGCTGACGCGGAAGAGATTTCG
CTCGATGATCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References