Detailed information of TA system TA188904

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2862151..2862791
• Replicon: chromosome
• Accession: NZ_CP069062
• Organism: Mycobacterium tuberculosis strain N0069

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: JN151_RS13365
• Protein ID: WP_003412970.1
• Coordinates: 2862151..2862570 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ09
• Locus tag: JN151_RS13370
• Protein ID: WP_003412975.1
• Coordinates: 2862567..2862791 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN151_RS13335	2857736..2858458	-	723	WP_003412957.1	DUF1906 domain-containing protein	-
JN151_RS13340	2858975..2859202	+	228	WP_003412960.1	type II toxin-antitoxin system VapB family antitoxin	-
JN151_RS13345	2859199..2859600	+	402	WP_003412963.1	PIN domain-containing protein	-
JN151_RS13350	2859635..2860555	-	921	WP_003412965.1	restriction endonuclease	-
JN151_RS13355	2860896..2861102	-	207	WP_229298035.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
JN151_RS13360	2861200..2862150	+	951	WP_003911916.1	ERCC4 domain-containing protein	-
JN151_RS13365	2862151..2862570	-	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN151_RS13370	2862567..2862791	-	225	WP_003412975.1	antitoxin VapB39	Antitoxin
JN151_RS13375	2862822..2865665	-	2844	WP_003899363.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
JN151_RS13380	2865737..2866138	-	402	WP_003412981.1	hypothetical protein	-
JN151_RS13385	2866138..2866608	-	471	WP_003412985.1	transcription antitermination factor NusB	-
JN151_RS13390	2866611..2867174	-	564	WP_003412989.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T188904 WP_003412970.1 NZ_CP069062:c2862570-2862151 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T188904 NZ_CP090591:c3972550-3972176 [Pectobacterium aroidearum]
ATGCAACTGCTTTCATTGATTGTGCATGGCCTATTAGTATTGCTCATTCTTCTGGCGCCGTGGCCGGACGGCTATGCATG
GCTGTGGCTATGCCTGGTCACGATGGTGATGTTCGGTTTTATCCGTAGCCAAAGGAATATCAAATCCCGGCAGGGGGAAA
TCGTTTTGCTCAGCGAAACGACCCTGAACTGGCGGCAGCAGGAATGGCAGATCGTTAAACGACCGTGGTTGCTGAAAAAT
GGCGTATTGCTGTCATTGCAGGCAGTGAACGGTAAAGACAGACAACAGCTGTGGCTGGCATCGGACAGCATGGGCGATGA
CGAATGGCGTCATCTGCGTCAGCTTCTTTTGCAGCAGAAAAACTGGGCGAGATAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7993.94 Da
• Isoelectric Point: 4.0057

>AT188904 WP_003412975.1 NZ_CP069062:c2862791-2862567 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Nucleotide

• Length: 225 bp

>AT188904 NZ_CP090591:c3972836-3972570 [Pectobacterium aroidearum]
ATGGAAATCGATAATAAATCACGCATTCATTGGGCATGCCGCCGGGGTATGCGTGAGTTGGATATCGCGATCATGCCGTT
TTTTGAGCATGACTACGACACACTCAGTGACAGCGATAAGCGCACGTTTGTGCGCCTGTTACAAAGCGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGCGAGCCGAAAGACGGAGAGCTGAAACGCATGATTTCTCTTATTCAAACGCGAAAT
AAAGATCGTGGCCCAGTGGCAATGTGA

Structures

Toxin

• AlphaFold DB: G0TQ08

Antitoxin

• AlphaFold DB: G0TQ09