Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2815968..2816620 Replicon chromosome
Accession NZ_CP069062
Organism Mycobacterium tuberculosis strain N0069

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag JN151_RS13170 Protein ID WP_003412752.1
Coordinates 2816195..2816620 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag JN151_RS13165 Protein ID WP_003412749.1
Coordinates 2815968..2816189 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN151_RS13150 2814208..2814414 - 207 WP_003899347.1 hypothetical protein -
JN151_RS13155 2814550..2815173 + 624 WP_003900858.1 TIGR00725 family protein -
JN151_RS13160 2815163..2815915 + 753 WP_003901416.1 hypothetical protein -
JN151_RS13165 2815968..2816189 + 222 WP_003412749.1 antitoxin Antitoxin
JN151_RS13170 2816195..2816620 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
JN151_RS13175 2816643..2817824 - 1182 WP_003899351.1 dihydrolipoamide acetyltransferase family protein -
JN151_RS13180 2817821..2818867 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
JN151_RS13185 2818878..2819981 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
JN151_RS13190 2820240..2821061 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
JN151_RS13195 2821058..2821615 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T188903 WP_003412752.1 NZ_CP069062:2816195-2816620 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T188903 NZ_CP090591:c3778232-3777744 [Pectobacterium aroidearum]
ATGATCTCCGCTCCTGAGCCACTCCACGCCGAACATGTACTATCTTCATTCTGTTGCGGCGTGGAGTCCATGGACAACTG
GCTAAAACAACGGGCGATGAAAAATCAGGTCACTGGCGCATCGCGAACTTTCGTCAGTTGTGATGGCTCAAAAGTGCTGG
CGTATTACTCATTGGCTTCCAGTGCCGTAGCAACGAATGCCGCTCCCGGACGTTTTCGTCGCAATATGCCCGATCCAATT
CCGGTGGTAGTGCTGGGTCGTCTGGCGGTGGATAAATCATTACATGGTCAGGGCGTTGGCCGAGCGCTGGTGCGCGATGT
CGGGCTGCGGGTGATTCAGGTGGCGGATACTATCGGCATTCGCGGGATGCTGGTTCATGCGTTGTCTGATGAAGCACGGG
AATTTTACCTACGCGTGGGGTTTGAGCCTTCGCCGATAGATCCGATGCTGTTGATGGTGACGTTGGGGGATTTGGTGGGG
AGTGTTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT188903 WP_003412749.1 NZ_CP069062:2815968-2816189 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT188903 NZ_CP090591:c3778522-3778229 [Pectobacterium aroidearum]
ATGCCAGCGACGAACAGCGTTTCTGTTAAACGCGAAACATTGAATTTACGCATCAAACCCGCAGAACGGGATCTGATTGA
TCGTGCAGCGAAGGCCAGAGGAAAAAATCGCACTGATTTTGTCCTTGAGGCTGCGCGTGCCGCCGCAGAGGAAGCGTTGA
TCGATCAGCGCATCATCATGGCAGATCCCGACGCTTATCAGGAATTCCTTACTCGCTTGGATCAGGCTCCTTCCCCGAAT
GCCGCGCTGCGCAAAACCATGCAAACGTCTGCACCGTGGGAACAGAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References