Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
Location | 2815968..2816620 | Replicon | chromosome |
Accession | NZ_CP069062 | ||
Organism | Mycobacterium tuberculosis strain N0069 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TPX1 |
Locus tag | JN151_RS13170 | Protein ID | WP_003412752.1 |
Coordinates | 2816195..2816620 (+) | Length | 142 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P9WJ24 |
Locus tag | JN151_RS13165 | Protein ID | WP_003412749.1 |
Coordinates | 2815968..2816189 (+) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JN151_RS13150 | 2814208..2814414 | - | 207 | WP_003899347.1 | hypothetical protein | - |
JN151_RS13155 | 2814550..2815173 | + | 624 | WP_003900858.1 | TIGR00725 family protein | - |
JN151_RS13160 | 2815163..2815915 | + | 753 | WP_003901416.1 | hypothetical protein | - |
JN151_RS13165 | 2815968..2816189 | + | 222 | WP_003412749.1 | antitoxin | Antitoxin |
JN151_RS13170 | 2816195..2816620 | + | 426 | WP_003412752.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
JN151_RS13175 | 2816643..2817824 | - | 1182 | WP_003899351.1 | dihydrolipoamide acetyltransferase family protein | - |
JN151_RS13180 | 2817821..2818867 | - | 1047 | WP_003412757.1 | 3-methyl-2-oxobutanoate dehydrogenase subunit beta | - |
JN151_RS13185 | 2818878..2819981 | - | 1104 | WP_003412761.1 | pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha | - |
JN151_RS13190 | 2820240..2821061 | - | 822 | WP_003412766.1 | citrate (pro-3S)-lyase subunit beta | - |
JN151_RS13195 | 2821058..2821615 | - | 558 | WP_003412768.1 | MaoC family dehydratase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 142 a.a. Molecular weight: 15392.89 Da Isoelectric Point: 9.2386
>T188903 WP_003412752.1 NZ_CP069062:2816195-2816620 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL
Download Length: 426 bp
>T188903 NZ_CP090591:c3778232-3777744 [Pectobacterium aroidearum]
ATGATCTCCGCTCCTGAGCCACTCCACGCCGAACATGTACTATCTTCATTCTGTTGCGGCGTGGAGTCCATGGACAACTG
GCTAAAACAACGGGCGATGAAAAATCAGGTCACTGGCGCATCGCGAACTTTCGTCAGTTGTGATGGCTCAAAAGTGCTGG
CGTATTACTCATTGGCTTCCAGTGCCGTAGCAACGAATGCCGCTCCCGGACGTTTTCGTCGCAATATGCCCGATCCAATT
CCGGTGGTAGTGCTGGGTCGTCTGGCGGTGGATAAATCATTACATGGTCAGGGCGTTGGCCGAGCGCTGGTGCGCGATGT
CGGGCTGCGGGTGATTCAGGTGGCGGATACTATCGGCATTCGCGGGATGCTGGTTCATGCGTTGTCTGATGAAGCACGGG
AATTTTACCTACGCGTGGGGTTTGAGCCTTCGCCGATAGATCCGATGCTGTTGATGGTGACGTTGGGGGATTTGGTGGGG
AGTGTTTAA
ATGATCTCCGCTCCTGAGCCACTCCACGCCGAACATGTACTATCTTCATTCTGTTGCGGCGTGGAGTCCATGGACAACTG
GCTAAAACAACGGGCGATGAAAAATCAGGTCACTGGCGCATCGCGAACTTTCGTCAGTTGTGATGGCTCAAAAGTGCTGG
CGTATTACTCATTGGCTTCCAGTGCCGTAGCAACGAATGCCGCTCCCGGACGTTTTCGTCGCAATATGCCCGATCCAATT
CCGGTGGTAGTGCTGGGTCGTCTGGCGGTGGATAAATCATTACATGGTCAGGGCGTTGGCCGAGCGCTGGTGCGCGATGT
CGGGCTGCGGGTGATTCAGGTGGCGGATACTATCGGCATTCGCGGGATGCTGGTTCATGCGTTGTCTGATGAAGCACGGG
AATTTTACCTACGCGTGGGGTTTGAGCCTTCGCCGATAGATCCGATGCTGTTGATGGTGACGTTGGGGGATTTGGTGGGG
AGTGTTTAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 7864.93 Da Isoelectric Point: 4.5258
>AT188903 WP_003412749.1 NZ_CP069062:2815968-2816189 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED
Download Length: 222 bp
>AT188903 NZ_CP090591:c3778522-3778229 [Pectobacterium aroidearum]
ATGCCAGCGACGAACAGCGTTTCTGTTAAACGCGAAACATTGAATTTACGCATCAAACCCGCAGAACGGGATCTGATTGA
TCGTGCAGCGAAGGCCAGAGGAAAAAATCGCACTGATTTTGTCCTTGAGGCTGCGCGTGCCGCCGCAGAGGAAGCGTTGA
TCGATCAGCGCATCATCATGGCAGATCCCGACGCTTATCAGGAATTCCTTACTCGCTTGGATCAGGCTCCTTCCCCGAAT
GCCGCGCTGCGCAAAACCATGCAAACGTCTGCACCGTGGGAACAGAAAAAATGA
ATGCCAGCGACGAACAGCGTTTCTGTTAAACGCGAAACATTGAATTTACGCATCAAACCCGCAGAACGGGATCTGATTGA
TCGTGCAGCGAAGGCCAGAGGAAAAAATCGCACTGATTTTGTCCTTGAGGCTGCGCGTGCCGCCGCAGAGGAAGCGTTGA
TCGATCAGCGCATCATCATGGCAGATCCCGACGCTTATCAGGAATTCCTTACTCGCTTGGATCAGGCTCCTTCCCCGAAT
GCCGCGCTGCGCAAAACCATGCAAACGTCTGCACCGTGGGAACAGAAAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TPX1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BW03 |