Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2333201..2333837 Replicon chromosome
Accession NZ_CP069062
Organism Mycobacterium tuberculosis strain N0069

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag JN151_RS10880 Protein ID WP_003904769.1
Coordinates 2333427..2333837 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag JN151_RS10875 Protein ID WP_003410651.1
Coordinates 2333201..2333434 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN151_RS10860 2328658..2329050 + 393 WP_229303073.1 metal ABC transporter permease -
JN151_RS10865 2329051..2329455 - 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
JN151_RS10870 2329539..2333123 - 3585 WP_003410648.1 cobaltochelatase subunit CobN -
JN151_RS10875 2333201..2333434 + 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
JN151_RS10880 2333427..2333837 + 411 WP_003904769.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
JN151_RS10885 2333821..2334912 + 1092 WP_003900454.1 precorrin-3B synthase -
JN151_RS10890 2334922..2335547 + 626 Protein_2151 precorrin-8X methylmutase -
JN151_RS10895 2335544..2337070 + 1527 WP_003410659.1 precorrin-2 C(20)-methyltransferase -
JN151_RS10900 2337016..2338239 - 1224 WP_003901321.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14176.35 Da        Isoelectric Point: 9.4835

>T188900 WP_003904769.1 NZ_CP069062:2333427-2333837 [Mycobacterium tuberculosis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMPAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

>T188900 NZ_CP090591:2899433-2899717 [Pectobacterium aroidearum]
ATGGAAATTAAATGGCTGCGTAAAGCCGCGGCCAATTTGGAAGCCGAATACCTCTATATCGCGCAAGACGATCCACAGGC
TGCCAGCCAGTTCGTAGATGAAGTCCAAAGATTAACGGAATTACTACCGCAACAGCCAGCAATGGGAAGGCCAGGCCGTG
TGCCAGGAACGCGTGAGCTGGTGTTAACGCACTATCCCTACATCATCCCCTACCGTGTGAAAGATAATATGCTCCAGATT
CTGCGCATCTTTCATACGCACAGACGTTTACCATCAAAATGGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT188900 WP_003410651.1 NZ_CP069062:2333201-2333434 [Mycobacterium tuberculosis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp

>AT188900 NZ_CP090591:2899764-2900003 [Pectobacterium aroidearum]
ATGGGTAATGTTACTTTCCGTATCGGTGACGATCTTAAAAAGCGCTCTTATGCAGCGCTTAAGAAACTGGGTATTACGCC
TTCTGAAGCATTTCGCCTCACGTTGGAATACATTGCTGAAAATGAAAGACTCCCATTTAAACAAAAGTTACTCAATGATG
AAGACGTAGAATTAGTTGAAGTTGTCCGTGAACGTCTTCGCAACCCCAAACCAGTACGCGTGACGCTGGATGATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7DU4
PDB 6A6X
AlphaFold DB A0A7U4BV50

References