188897

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2241678..2242264 Replicon chromosome
Accession NZ_CP069062
Organism Mycobacterium tuberculosis strain N0069

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag JN151_RS10485 Protein ID WP_003410010.1
Coordinates 2241678..2242022 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag JN151_RS10490 Protein ID WP_003410014.1
Coordinates 2242016..2242264 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN151_RS10450 2237384..2237983 + 600 WP_003409989.1 L-lysine exporter -
JN151_RS10455 2238399..2238827 + 429 WP_003409992.1 cellulose-binding protein -
JN151_RS10460 2239053..2239592 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
JN151_RS10465 2240112..2240672 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
JN151_RS10470 2240669..2241010 - 342 WP_003410003.1 DUF2384 domain-containing protein -
JN151_RS10475 2241096..2241353 + 258 WP_003410006.1 hypothetical protein -
JN151_RS10480 2241254..2241589 - 336 WP_003410009.1 dehydrogenase -
JN151_RS10485 2241678..2242022 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
JN151_RS10490 2242016..2242264 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
JN151_RS10495 2242363..2244678 - 2316 WP_003899120.1 cation transporter ATPase CptG -
JN151_RS10500 2244675..2244947 - 273 WP_003903706.1 DUF1490 family protein -
JN151_RS10505 2245000..2245356 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
JN151_RS10510 2245513..2246280 + 768 WP_003410019.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T188897 WP_003410010.1 NZ_CP069062:c2242022-2241678 [Mycobacterium tuberculosis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

>T188897 NZ_CP090591:173940-174215 [Pectobacterium aroidearum]
ATGCAGGGAAAAATAGCCAGTCTACGAAAAAAGCAGCGAGAAACGCTGAGCCAAATTTTCAAAACACCCGTGCTTTCAGG
TGTTAAATGGTCAAATGTTGAGTCACTCATCACTGCGTTAGGTGGTGAAATTAAGGAAGGTAGCGGGTCACGGGTGCGAT
TTTTATTGAATGGGAGTATCGCCCGGTTCCATCGTCCTCACCCGTCACCGGATACTGATAAAGGCGCATTGGTTAACCTG
CGTGAATGGTTGGAAAGTATAGGAGTAAAACCATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT188897 WP_003410014.1 NZ_CP069062:c2242264-2242016 [Mycobacterium tuberculosis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp

>AT188897 NZ_CP090591:174212-174574 [Pectobacterium aroidearum]
ATGACTAAAGCACTTAACACACCAAATACGATGGTTGTTTCCGGCCAACCGGCCATTATCAGCTATGTACCGGAAATCGG
TATGTTTCGCGGTAAGTTTATTGGCTTATCTGGCTACTGTGATTTTGTCGCTGACAGTATTAATGGGCTGAGAAACGAGG
GCGAAATTTCGCTACGTGAATATCTGGAAGACTGTCAGGAAAATGGCATTGAACCTTACGAACGTGAAGAGAAGGTGAAA
ACGTTCACTCTCCGTTATCCTGAATCATTCGGAGAACGACTGACTATTGCGGCGGCTGAACGTCAAATTTCAGTGAATAC
GTTTATTGTCGAAACGCTTAATGAACGTATGAAACAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAW9

References