Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mbcAT/RES-TIGR02293 |
| Location | 2240112..2241010 | Replicon | chromosome |
| Accession | NZ_CP069062 | ||
| Organism | Mycobacterium tuberculosis strain N0069 | ||
Toxin (Protein)
| Gene name | mbcT | Uniprot ID | P64908 |
| Locus tag | JN151_RS10465 | Protein ID | WP_003410001.1 |
| Coordinates | 2240112..2240672 (-) | Length | 187 a.a. |
Antitoxin (Protein)
| Gene name | mbcA | Uniprot ID | P64910 |
| Locus tag | JN151_RS10470 | Protein ID | WP_003410003.1 |
| Coordinates | 2240669..2241010 (-) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN151_RS10435 | 2235281..2235934 | - | 654 | WP_003409976.1 | cutinase Cfp21 | - |
| JN151_RS10440 | 2236049..2236279 | + | 231 | WP_003409980.1 | DUF167 domain-containing protein | - |
| JN151_RS10445 | 2236364..2237275 | - | 912 | WP_003409986.1 | ArgP/LysG family DNA-binding transcriptional regulator | - |
| JN151_RS10450 | 2237384..2237983 | + | 600 | WP_003409989.1 | L-lysine exporter | - |
| JN151_RS10455 | 2238399..2238827 | + | 429 | WP_003409992.1 | cellulose-binding protein | - |
| JN151_RS10460 | 2239053..2239592 | + | 540 | WP_003900446.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) | - |
| JN151_RS10465 | 2240112..2240672 | - | 561 | WP_003410001.1 | RES family NAD+ phosphorylase | Toxin |
| JN151_RS10470 | 2240669..2241010 | - | 342 | WP_003410003.1 | DUF2384 domain-containing protein | Antitoxin |
| JN151_RS10475 | 2241096..2241353 | + | 258 | WP_003410006.1 | hypothetical protein | - |
| JN151_RS10480 | 2241254..2241589 | - | 336 | WP_003410009.1 | dehydrogenase | - |
| JN151_RS10485 | 2241678..2242022 | - | 345 | WP_003410010.1 | type II toxin-antitoxin system toxin endoribonuclease MazF6 | - |
| JN151_RS10490 | 2242016..2242264 | - | 249 | WP_003410014.1 | ribbon-helix-helix protein, CopG family | - |
| JN151_RS10495 | 2242363..2244678 | - | 2316 | WP_003899120.1 | cation transporter ATPase CptG | - |
| JN151_RS10500 | 2244675..2244947 | - | 273 | WP_003903706.1 | DUF1490 family protein | - |
| JN151_RS10505 | 2245000..2245356 | - | 357 | WP_003410018.1 | Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 187 a.a. Molecular weight: 20248.70 Da Isoelectric Point: 4.5091
>T188896 WP_003410001.1 NZ_CP069062:c2240672-2240112 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT
Download Length: 561 bp
>T188896 NZ_CP090591:c29907-29521 [Pectobacterium aroidearum]
ATGGAGGTTTACAGATTGGCATGGGAAATTGTCACACGGGCGCTATTCGATACGTGGTTTGATGAGCAAACCGAAACGGT
ACAGGAAGAGGTTTTGGCACACCTCGGTATACTCGAAGAAGATGGCCCACAGCTAGGACGACCACAGGTTGATCAGATTA
AAGGCTCACAATACAAAAATATGAAGGAGCTTCGAGTTCAGGTTGGCGGCCACCCATTCCGAACATTCTTCGCGTTTGAC
CGGACACGTAAAGCGATTGTTTTATGTGCGGGAGATAAGAAAGGCGAAAATGAAAAATTGTTCTACGAACGTATGATTAA
GATCGCAGACGCTGAGTTTACATCGCATCTGATATCACCGGAGGTAAAAGAAGATGGCGACATTTAA
ATGGAGGTTTACAGATTGGCATGGGAAATTGTCACACGGGCGCTATTCGATACGTGGTTTGATGAGCAAACCGAAACGGT
ACAGGAAGAGGTTTTGGCACACCTCGGTATACTCGAAGAAGATGGCCCACAGCTAGGACGACCACAGGTTGATCAGATTA
AAGGCTCACAATACAAAAATATGAAGGAGCTTCGAGTTCAGGTTGGCGGCCACCCATTCCGAACATTCTTCGCGTTTGAC
CGGACACGTAAAGCGATTGTTTTATGTGCGGGAGATAAGAAAGGCGAAAATGAAAAATTGTTCTACGAACGTATGATTAA
GATCGCAGACGCTGAGTTTACATCGCATCTGATATCACCGGAGGTAAAAGAAGATGGCGACATTTAA
Antitoxin
Download Length: 114 a.a. Molecular weight: 12488.33 Da Isoelectric Point: 4.8359
>AT188896 WP_003410003.1 NZ_CP069062:c2241010-2240669 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV
Download Length: 342 bp
>AT188896 NZ_CP090591:c29534-29235 [Pectobacterium aroidearum]
ATGGCGACATTTAAAGAAATGATGGCTAAACGTTCACCGGAGAGCCGCGCCCGCATTGAAGCGCGCACGGCTGAGATCCG
TCAGGAAATCACTTTAGCGAAACTACGCGAAGAGCTGAACATGTCGCAGACTCAGCTTGCATTAGCTCTGGGCGTCAAGC
AGCCATCTATTGTTAAGATGGAGAAGGTCGAGAATGACCCAAAACTGTCAACGCTGAAACGCTATGTCACAGCCCTAGGC
GGCAAGCTTACGCTAGATGTGACCTTGCCTGATGGTAAGCGTATCGCGCTTACTTTGTAA
ATGGCGACATTTAAAGAAATGATGGCTAAACGTTCACCGGAGAGCCGCGCCCGCATTGAAGCGCGCACGGCTGAGATCCG
TCAGGAAATCACTTTAGCGAAACTACGCGAAGAGCTGAACATGTCGCAGACTCAGCTTGCATTAGCTCTGGGCGTCAAGC
AGCCATCTATTGTTAAGATGGAGAAGGTCGAGAATGACCCAAAACTGTCAACGCTGAAACGCTATGTCACAGCCCTAGGC
GGCAAGCTTACGCTAGATGTGACCTTGCCTGATGGTAAGCGTATCGCGCTTACTTTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|