Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2232786..2233474 Replicon chromosome
Accession NZ_CP069062
Organism Mycobacterium tuberculosis strain N0069

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag JN151_RS10420 Protein ID WP_003409958.1
Coordinates 2232786..2233205 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag JN151_RS10425 Protein ID WP_003409968.1
Coordinates 2233214..2233474 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN151_RS10400 2228281..2229129 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
JN151_RS10405 2229092..2230537 - 1446 WP_003409946.1 APC family permease -
JN151_RS10410 2230716..2231402 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
JN151_RS10415 2231593..2232561 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
JN151_RS10420 2232786..2233205 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
JN151_RS10425 2233214..2233474 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN151_RS10430 2233617..2235293 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
JN151_RS10435 2235281..2235934 - 654 WP_003409976.1 cutinase Cfp21 -
JN151_RS10440 2236049..2236279 + 231 WP_003409980.1 DUF167 domain-containing protein -
JN151_RS10445 2236364..2237275 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JN151_RS10450 2237384..2237983 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T188895 WP_003409958.1 NZ_CP069062:c2233205-2232786 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T188895 NZ_CP090590:4725257-4725544 [Pectobacterium aroidearum]
ATGAGCTATAGCGTCAAATTCAGGGAAGATGCGCTGAAAGAATGGCTCAAGCTCGATAAAACCATCCAGCAGCAATTTGC
CAAAAAACTAAAAAAATGCTGCGAAAATCCCCATATTCCTTCGGCAAAATTACGGGGGATGAAGGACTGCTACAAAATAA
AGCTCCGAGCATCAGGCTTTCGTTTGGTTTATGAAGTCATTGACGATGTATTGATTATCGCCGTAGTGGCGGTAGGTAAA
CGTGAACGCAGTGGCGTTTATCATCTGGCGAGTGAGCGAATGAGATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT188895 WP_003409968.1 NZ_CP069062:c2233474-2233214 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT188895 NZ_CP090590:4725009-4725260 [Pectobacterium aroidearum]
ATGCCGAATATTATATTGAGTGATACCAGTGCCAGCGTCAGTGAATTGAAAAAGAACCCGATGGCGACAGTCAATGCTGG
CGACGGTCTACCTGTCGCTATTTTGAACCGCAACCAGCCTGCGTTTTATTGCATTCCTGCGGATCTCTACGAAAAAATGC
TGGATGCGCTGGACGATCAAGAACTGGTTAAGCTAATCGGTGAACGCAAAAACCAGCCACTGGTTGACGTGGATTTGGAT
AGTTTCTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References