Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/ParE-RHH |
Location | 2206666..2207210 | Replicon | chromosome |
Accession | NZ_CP069062 | ||
Organism | Mycobacterium tuberculosis strain N0069 |
Toxin (Protein)
Gene name | parE | Uniprot ID | G0TLU9 |
Locus tag | JN151_RS10270 | Protein ID | WP_003409896.1 |
Coordinates | 2206666..2206962 (-) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | P67299 |
Locus tag | JN151_RS10275 | Protein ID | WP_003409899.1 |
Coordinates | 2206959..2207210 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JN151_RS10215 | 2201699..2202049 | - | 351 | WP_003409871.1 | hypothetical protein | - |
JN151_RS10220 | 2202060..2202962 | - | 903 | WP_003409874.1 | hypothetical protein | - |
JN151_RS10225 | 2202983..2203174 | - | 192 | WP_003409876.1 | hypothetical protein | - |
JN151_RS10230 | 2203175..2203471 | - | 297 | WP_003409877.1 | hypothetical protein | - |
JN151_RS10235 | 2203711..2203926 | + | 216 | WP_003409878.1 | antitoxin | - |
JN151_RS10240 | 2203923..2204234 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
JN151_RS10245 | 2204208..2204729 | - | 522 | WP_003904745.1 | hypothetical protein | - |
JN151_RS10250 | 2204704..2205081 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
JN151_RS10255 | 2205123..2205572 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
JN151_RS10260 | 2205569..2206114 | + | 546 | WP_031663732.1 | hypothetical protein | - |
JN151_RS10265 | 2206003..2206617 | - | 615 | WP_003901296.1 | hypothetical protein | - |
JN151_RS10270 | 2206666..2206962 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
JN151_RS10275 | 2206959..2207210 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
JN151_RS10280 | 2207197..2207691 | + | 495 | WP_003899099.1 | hypothetical protein | - |
JN151_RS10285 | 2207851..2208258 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
JN151_RS10290 | 2208262..2208534 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
JN151_RS10295 | 2208567..2209787 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
JN151_RS10300 | 2210686..2211483 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T188894 WP_003409896.1 NZ_CP069062:c2206962-2206666 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T188894 NZ_CP090590:c4411939-4411652 [Pectobacterium aroidearum]
ATGATCTATAAGTTAAAATTTGTGCCTTCTGCAATGAAGGAATGGAAAAAATTAGGGCATCCTGTCAGGGAACAATTCAA
AAAAAAGCTAGTTGAGCGTTTAGAAAATCCTCGTGTTCCTTCAGCCCAGCTTCATGGTCGTAAAGACCAGTATAAAATTA
AACTGAAGTCTGCTGGCTACAGACTGGTATATTTGGTTCAGGATGAGACCATTACGGTGATGGTCATGGGGGGTGGAAAG
CGCGAAGGTAGTCAGGTTTATTCTGATACTAAAGGTCGCTCTGCTTAA
ATGATCTATAAGTTAAAATTTGTGCCTTCTGCAATGAAGGAATGGAAAAAATTAGGGCATCCTGTCAGGGAACAATTCAA
AAAAAAGCTAGTTGAGCGTTTAGAAAATCCTCGTGTTCCTTCAGCCCAGCTTCATGGTCGTAAAGACCAGTATAAAATTA
AACTGAAGTCTGCTGGCTACAGACTGGTATATTTGGTTCAGGATGAGACCATTACGGTGATGGTCATGGGGGGTGGAAAG
CGCGAAGGTAGTCAGGTTTATTCTGATACTAAAGGTCGCTCTGCTTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT188894 WP_003409899.1 NZ_CP069062:c2207210-2206959 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT188894 NZ_CP090590:c4412183-4411929 [Pectobacterium aroidearum]
ATGGCTTTCAATATCCTAACTAACACAGCGGCCAGCATCACTGAACTGAAACGCGACCCAATGGGGACAGTACGGGCTGC
TGAAGGTGAGACTATCGCTATACTGAACCGGAATGAGCCTGCGTTCTATTGTGTGCCTCCTGCCATGTTCGCTTATTTAA
TGGAATTGGCTGAAGATGCAGAGCTGGGGCGTACTGTTGATGATCGTATGTCAGAGTTAGCTGACGCGGAAGAGATTTCG
CTCGATGATCTATAA
ATGGCTTTCAATATCCTAACTAACACAGCGGCCAGCATCACTGAACTGAAACGCGACCCAATGGGGACAGTACGGGCTGC
TGAAGGTGAGACTATCGCTATACTGAACCGGAATGAGCCTGCGTTCTATTGTGTGCCTCCTGCCATGTTCGCTTATTTAA
TGGAATTGGCTGAAGATGCAGAGCTGGGGCGTACTGTTGATGATCGTATGTCAGAGTTAGCTGACGCGGAAGAGATTTCG
CTCGATGATCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TLU9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BUZ2 |