Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2206666..2207210 Replicon chromosome
Accession NZ_CP069062
Organism Mycobacterium tuberculosis strain N0069

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag JN151_RS10270 Protein ID WP_003409896.1
Coordinates 2206666..2206962 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag JN151_RS10275 Protein ID WP_003409899.1
Coordinates 2206959..2207210 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN151_RS10215 2201699..2202049 - 351 WP_003409871.1 hypothetical protein -
JN151_RS10220 2202060..2202962 - 903 WP_003409874.1 hypothetical protein -
JN151_RS10225 2202983..2203174 - 192 WP_003409876.1 hypothetical protein -
JN151_RS10230 2203175..2203471 - 297 WP_003409877.1 hypothetical protein -
JN151_RS10235 2203711..2203926 + 216 WP_003409878.1 antitoxin -
JN151_RS10240 2203923..2204234 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
JN151_RS10245 2204208..2204729 - 522 WP_003904745.1 hypothetical protein -
JN151_RS10250 2204704..2205081 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
JN151_RS10255 2205123..2205572 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
JN151_RS10260 2205569..2206114 + 546 WP_031663732.1 hypothetical protein -
JN151_RS10265 2206003..2206617 - 615 WP_003901296.1 hypothetical protein -
JN151_RS10270 2206666..2206962 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN151_RS10275 2206959..2207210 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
JN151_RS10280 2207197..2207691 + 495 WP_003899099.1 hypothetical protein -
JN151_RS10285 2207851..2208258 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
JN151_RS10290 2208262..2208534 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN151_RS10295 2208567..2209787 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
JN151_RS10300 2210686..2211483 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T188894 WP_003409896.1 NZ_CP069062:c2206962-2206666 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T188894 NZ_CP090590:c4411939-4411652 [Pectobacterium aroidearum]
ATGATCTATAAGTTAAAATTTGTGCCTTCTGCAATGAAGGAATGGAAAAAATTAGGGCATCCTGTCAGGGAACAATTCAA
AAAAAAGCTAGTTGAGCGTTTAGAAAATCCTCGTGTTCCTTCAGCCCAGCTTCATGGTCGTAAAGACCAGTATAAAATTA
AACTGAAGTCTGCTGGCTACAGACTGGTATATTTGGTTCAGGATGAGACCATTACGGTGATGGTCATGGGGGGTGGAAAG
CGCGAAGGTAGTCAGGTTTATTCTGATACTAAAGGTCGCTCTGCTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT188894 WP_003409899.1 NZ_CP069062:c2207210-2206959 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT188894 NZ_CP090590:c4412183-4411929 [Pectobacterium aroidearum]
ATGGCTTTCAATATCCTAACTAACACAGCGGCCAGCATCACTGAACTGAAACGCGACCCAATGGGGACAGTACGGGCTGC
TGAAGGTGAGACTATCGCTATACTGAACCGGAATGAGCCTGCGTTCTATTGTGTGCCTCCTGCCATGTTCGCTTATTTAA
TGGAATTGGCTGAAGATGCAGAGCTGGGGCGTACTGTTGATGATCGTATGTCAGAGTTAGCTGACGCGGAAGAGATTTCG
CTCGATGATCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References