Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1962979..1963439 Replicon chromosome
Accession NZ_CP069062
Organism Mycobacterium tuberculosis strain N0069

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag JN151_RS09155 Protein ID WP_003898996.1
Coordinates 1963191..1963439 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag JN151_RS09150 Protein ID WP_003408528.1
Coordinates 1962979..1963191 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN151_RS09135 1959457..1960644 - 1188 WP_003898992.1 nitrate transporter NarK -
JN151_RS09140 1960931..1961215 + 285 WP_003408522.1 DUF1876 domain-containing protein -
JN151_RS09145 1961229..1962911 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
JN151_RS09150 1962979..1963191 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN151_RS09155 1963191..1963439 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
JN151_RS09160 1963447..1964184 + 738 WP_003898997.1 hypothetical protein -
JN151_RS09165 1964278..1965978 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
JN151_RS09170 1966263..1966664 - 402 WP_003408538.1 hypothetical protein -
JN151_RS09175 1966654..1967265 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T188891 WP_003898996.1 NZ_CP069062:1963191-1963439 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T188891 NZ_CP090590:4193483-4194412 [Pectobacterium aroidearum]
ATGGATCATCGTGATATTTATGCCCGACAGGTCAAGCTGTTAATGACCGCCCTGCCGTATGTGGCGAAAGAACCCTGTTT
CGCACTGAAAGGCGGCACCGCAATTAATTTATTTGTGCAGGATTTTCCTCGTCTATCGGTAGATATCGATCTGGTTTATC
AAACCTTCATAGATCGTGATACAGACCTAATCGCTATTGACGATGCATTGATGCGTATTACGGAATCGCTGAATGGCAGA
CAGGGGCTCACAGCGATCCAGCAGGAGAATAAAGCCGATGAAAAACGCATCATCGTTAATACCGCTGATGCGCAGATAAA
GATTGAAGTCAGCCCGGTCTGGCGTGGACTGCTGTTGCCCCCAGCAGAAATGCCGGTATGTGAGCAGGTGGAAATGGAAT
ACGGCTTCACCACCATGAGCGTTGTCTCTCTGGCAGATCTTTACGGCGGCAAAATCTGCGCTGCGCTTGACCGCCAGCAT
CCGCGCGATCTGTTTGATGTACTGAATATGCTAGAAAAACCGTGCCTAACGCGTGAGATTTTTGATGGTTTTCTTTGCTA
TCTGGCAGGACATCCTCGCCCTATTGCCGAACTACTGGCACCGAATTGGGACACATCGCGGATCGCCACACTATACGCCC
AGGAATTTTCAGGCATGACGCAGCAGGAAACCTCACTGGAATCGCTGTTATCTGTAGCGACTCTACTGCCGCAGGCGTTG
AAATCTCATTTCACCGCTCAGGACCGGCAATTCTTACTCAGCTATAAGCAAAACAACCCTGACTGGTCGCTGTATCGCTA
TCCTGATATTCAACATCTTCCCGCCATTCGCTGGAAACAGCGGAATTTATCGGCTTTACATGCTAAAAATCCGGCCAAAT
TTAGCGCGGCAGTAGGTAAGCTTGAGAAGGTTCTGGAACAACATTTTTAG

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT188891 WP_003408528.1 NZ_CP069062:1962979-1963191 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT188891 NZ_CP090590:4192714-4193496 [Pectobacterium aroidearum]
TTGACAAATTATCTAAACTGGCTGATGCAAAACACCCTGCCCGGTCAGGTGTTGCTACAGTCATGGCTTACCCGCAACGG
CATAGACCGTAAGCTCTCTTACGTCTATGTCCAAAACGGTTGGCTCAGGCGGATCGCTCACGGCGTTTACTGCCGGACGG
GTCGTGAACCAGACTGGGTGGATGCGGTTTACTGCCTGCAAACTCAATGGGAGAAACCTGTGCGGGTAGCAGGGCTGACC
AGCCTTGCGCTACAGGGCTATTCCCATTATACCGAACTGGGTAAACCTCAAATTTGGCTCACGCTCCCGGCTTACATAAA
GCTGCCGGGATGGTTCACCGCCTTTAAACCATCCGCCACCTTTGTCGTGCTCTATACATCAGGCCTGTCGGTTGATGTGA
TGCCACTCACGACAGAACTGAGAATCGGCGATCGGCGGCTGACTGGCAGCATGCCAGAACTTGCCGCATATGAAATCGCC
AGCGGCGTTCCCGCACAAATATCGTTTGAGCATGCAGATGCATTGTTTCAGGGGCTGAACCTTCTCAGTCCGCGTAAATT
ACAGGCACTGCTCTATGCCAGCCATTCGGTAAAAACCAACAGGGTGATGCTCTACCTTGCCCAGCGCAATGGACATCCTT
ATTTTCAGTATCTCGATAAAAGTGGTATAGAAACAGGCGCTGGAAAGCGGCAAATTGTCCCCGGTGGCTGGCTGGAACCG
GATTACCAGATCACGGTTCCCAGGGAGTTTAAATCGGAAGGAGTCGAAGATGGATCATCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References