Detailed information of TA system TA188890

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1942304..1942917
• Replicon: chromosome
• Accession: NZ_CP069062
• Organism: Mycobacterium tuberculosis strain N0069

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JN151_RS09045
• Protein ID: WP_244749427.1
• Coordinates: 1942304..1942693 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WJ52
• Locus tag: JN151_RS09050
• Protein ID: WP_003408469.1
• Coordinates: 1942690..1942917 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN151_RS09010	1937933..1938847	+	915	WP_031663714.1	3-hydroxyacyl-CoA dehydrogenase family protein	-
JN151_RS09015	1938850..1939680	+	831	WP_003408448.1	cyclase family protein	-
JN151_RS09020	1939680..1940030	+	351	WP_003898986.1	cupin domain-containing protein	-
JN151_RS09025	1940083..1940901	+	819	WP_244749426.1	3-keto-5-aminohexanoate cleavage protein	-
JN151_RS09030	1940915..1941694	+	780	WP_003408460.1	IclR family transcriptional regulator	-
JN151_RS09040	1942125..1942256	+	132	Protein_1782	IS3 family transposase	-
JN151_RS09045	1942304..1942693	-	390	WP_244749427.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN151_RS09050	1942690..1942917	-	228	WP_003408469.1	antitoxin	Antitoxin
JN151_RS09055	1943135..1944619	+	1485	WP_003408473.1	biotin carboxylase	-
JN151_RS09060	1944616..1945863	+	1248	WP_003408476.1	serine hydrolase	-
JN151_RS09065	1945906..1946325	-	420	WP_031663715.1	hypothetical protein	-
JN151_RS09070	1946315..1947025	-	711	WP_003408486.1	winged helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (3-117)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 13759.94 Da
• Isoelectric Point: 7.4757

>T188890 WP_244749427.1 NZ_CP069062:c1942693-1942304 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAAGLGVPLITCDGRLAQSHGHNAEIELVA

Nucleotide

• Length: 390 bp

>T188890 NZ_CP090590:c3948710-3948336 [Pectobacterium aroidearum]
ATGCAACTGCTTTCATTGATTGTGCATGGCCTATTAGTATTGCTCATTCTTCTGGCGCCGTGGCCGGACGGCTATGCATG
GCTGTGGCTATGCCTGGTCACGATGGTGATGTTCGGTTTTATCCGTAGCCAAAGGAATATCAAATCCCGGCAGGGGGAAA
TCGTTTTGCTCAGCGAAACGACCCTGAACTGGCGGCAGCAGGAATGGCAGATCGTTAAACGACCGTGGTTGCTGAAAAAT
GGCGTATTGCTGTCATTGCAGGCAGTGAACGGTAAAGACAGACAACAGCTGTGGCTGGCATCGGACAGCATGGGCGATGA
CGAATGGCGTCATCTGCGTCAGCTTCTTTTGCAGCAGAAAAACTGGGCGAGATAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8226.39 Da
• Isoelectric Point: 4.3313

>AT188890 WP_003408469.1 NZ_CP069062:c1942917-1942690 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Nucleotide

• Length: 228 bp

>AT188890 NZ_CP090590:c3948996-3948730 [Pectobacterium aroidearum]
ATGGAAATCGATAATAAATCACGCATTCATTGGGCATGCCGCCGGGGTATGCGTGAGTTGGATATCGCGATCATGCCGTT
TTTTGAGCATGACTACGACACACTCAGTGACAGCGATAAGCGCACGTTTGTGCGCCTGTTACAAAGCGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGCGAGCCGAAAGACGGAGAGCTGAAACGCATGATTTCTCTTATTCAAACGCGAAAT
AAAGATCGTGGCCCAGTGGCAATGTGA

Structures

Antitoxin

• PDB: 7E4J
• AlphaFold DB: A0A7U4FAN9