Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1543836..1544886 Replicon chromosome
Accession NZ_CP069062
Organism Mycobacterium tuberculosis strain N0069

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag JN151_RS07295 Protein ID WP_003407164.1
Coordinates 1543836..1544657 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag JN151_RS07300 Protein ID WP_003407167.1
Coordinates 1544650..1544886 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN151_RS07275 1539394..1540056 - 663 WP_003407152.1 membrane protein -
JN151_RS07280 1540053..1540838 - 786 WP_003407157.1 membrane protein -
JN151_RS07285 1541129..1543090 - 1962 WP_003407159.1 sigma-F factor regulator -
JN151_RS07290 1543229..1543615 - 387 WP_003898845.1 anti-sigma-F factor antagonist RsfA -
JN151_RS07295 1543836..1544657 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
JN151_RS07300 1544650..1544886 + 237 WP_003407167.1 hypothetical protein Antitoxin
JN151_RS07305 1544958..1546163 - 1206 WP_003918234.1 serine hydrolase domain-containing protein -
JN151_RS07310 1546466..1547251 + 786 WP_003407180.1 lipoprotein LprF -
JN151_RS07315 1547447..1548916 + 1470 WP_003900326.1 cytochrome b5 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T188886 WP_003407164.1 NZ_CP069062:1543836-1544657 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

>T188886 NZ_CP090590:2875593-2875877 [Pectobacterium aroidearum]
ATGGAAATTAAATGGCTGCGTAAAGCCGCGGCCAATTTGGAAGCCGAATACCTCTATATCGCGCAAGACGATCCACAGGC
TGCCAGCCAGTTCGTAGATGAAGTCCAAAGATTAACGGAATTACTACCGCAACAGCCAGCAATGGGAAGGCCAGGCCGTG
TGCCAGGAACGCGTGAGCTGGTGTTAACGCACTATCCCTACATCATCCCCTACCGTGTGAAAGATAATATGCTCCAGATT
CTGCGCATCTTTCATACGCACAGACGTTTACCATCAAAATGGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT188886 WP_003407167.1 NZ_CP069062:1544650-1544886 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp

>AT188886 NZ_CP090590:2875924-2876163 [Pectobacterium aroidearum]
ATGGGTAATGTTACTTTCCGTATCGGTGACGATCTTAAAAAGCGCTCTTATGCAGCGCTTAAGAAACTGGGTATTACGCC
TTCTGAAGCATTTCGCCTCACGTTGGAATACATTGCTGAAAATGAAAGACTCCCATTTAAACAAAAGTTACTCAATGATG
AAGACGTAGAATTAGTTGAAGTTGTCCGTGAACGTCTTCGCAACCCCAAACCAGTACGCGTGACGCTGGATGATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References