Detailed information of TA system TA188884

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1385251..1385939
• Replicon: chromosome
• Accession: NZ_CP069062
• Organism: Mycobacterium tuberculosis strain N0069

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: JN151_RS06605
• Protein ID: WP_003406304.1
• Coordinates: 1385508..1385939 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: JN151_RS06600
• Protein ID: WP_003406302.1
• Coordinates: 1385251..1385511 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN151_RS06580	1380827..1381651	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
JN151_RS06585	1381656..1382837	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
JN151_RS06590	1382915..1384015	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
JN151_RS06595	1384186..1385175	+	990	WP_003406301.1	malate dehydrogenase	-
JN151_RS06600	1385251..1385511	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
JN151_RS06605	1385508..1385939	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN151_RS06610	1385962..1387648	-	1687	Protein_1305	PE family protein	-
JN151_RS06615	1387828..1388688	+	861	WP_003903377.1	glycine betaine ABC transporter substrate-binding protein	-
JN151_RS06620	1388769..1389599	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
JN151_RS06625	1389656..1389949	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
JN151_RS06630	1389946..1390215	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T188884 WP_003406304.1 NZ_CP069062:1385508-1385939 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T188884 NZ_CP090590:c211701-211522 [Pectobacterium aroidearum]
ATGGATAGCAGGACGTTAATCGCAGAAATCAAGGCCGATGGGTGGGAGCTGATACGAGTGAACGGAAGCCACCACCATTT
TATGCACCCCAGCAAACCGGGATTAGTCACAATCCCCCACCCCAAGAAAGATTTACCAATAGGTACGGTAAAAAGCATCA
GGAAACAGGCAGGAATATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT188884 WP_003406302.1 NZ_CP069062:1385251-1385511 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT188884 NZ_CP090590:c211494-211084 [Pectobacterium aroidearum]
ATGTTTTATCCCATTGCAATTGAAGCAGGCGACGATACTCACGCATACGGCGTAACAGTACCAGATTTACCGGGCTGTTT
TTCTGCAGGCGATACGCTAGACGATGCTATCGCGAATGCTAAAGAAGCGATTACCGGACATATCGAGCTACTGGTTGAGA
TGGGTCAGGATATTCCCACCGTATCAACAGTAGGTCAGTTGGCAAAAAGGTCTGAGTATGCAGGGTACACGTGGGCGGTT
GTTGATATTGATGTAACTCGTTTAATGGGCGGCTCAGAAAAAATTAACGTTACATTGCCCAAATCGCTGATTGACCGCAT
TGATCGTTGCGTGGCGAGTAATCCAGAATTTAAAAGTCGTTCGGGTTTTCTTGCACAGGCGGCATTAGAGCGAATTTCGT
CTTCCCGATGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6