Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 756386..757019 Replicon chromosome
Accession NZ_CP069062
Organism Mycobacterium tuberculosis strain N0069

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag JN151_RS03465 Protein ID WP_003403365.1
Coordinates 756386..756769 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag JN151_RS03470 Protein ID WP_003403368.1
Coordinates 756864..757019 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN151_RS03440 751678..752214 + 537 WP_003403341.1 50S ribosomal protein L10 -
JN151_RS03445 752251..752643 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
JN151_RS03450 752636..753331 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
JN151_RS03455 753402..754907 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
JN151_RS03460 754988..755998 + 1011 WP_031653722.1 ABC transporter ATP-binding protein -
JN151_RS03465 756386..756769 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
JN151_RS03470 756864..757019 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN151_RS03475 757095..757811 - 717 WP_003903122.1 CPBP family intramembrane metalloprotease -
JN151_RS03480 758087..758395 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
JN151_RS03485 758382..758627 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
JN151_RS03490 758737..759174 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
JN151_RS03495 759171..759425 - 255 WP_003911263.1 antitoxin VapB7 -
JN151_RS03500 759539..761902 + 2364 WP_003403397.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T188874 WP_003403365.1 NZ_CP069062:c756769-756386 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T188874 NZ_CP090589:3769147-3769452 [Pectobacterium aroidearum]
ATGCAATTCATTGTTTATGAATATAAACGCGCCAGCCACTACAAAATGTTTGTCGATGTGCAAAGCGATATTGTCGACAC
ACCAAAGCGGCGCATGGTCATCCCGCTTATCGAAGCACATCACCTGTCTGAGAAAGTGAATAAGACGTTGTTCCCTCTGA
TCCGCATCGATGGCGAAGATTATCGGCTGATGACAACTGAACTATCGAGCGTTCCCGTTGAAGTCATTGGTGAGGCTATC
GCGGATCTTGGCGACTACGCGGATGAGGTCAAAGATGCTATTAATCTGATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT188874 WP_003403368.1 NZ_CP069062:c757019-756864 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT188874 NZ_CP090589:3768926-3769144 [Pectobacterium aroidearum]
ATGAAACACCGCGTCAGCGTTACCGTGGACAAAGACAGTTATCAGGTTCTGAGTGCTGCCGGAGTCAATATTTCCGGGCT
GGTGAACGATGCCATTGGCAAAGAAGCCCGCCGTATCAAGGCTGAAGAATGGAAGAAGGAAAACCGCGAAGGGATGGAAG
AAGTCGCCCGATTTATCGCACAACATGGCTCCTTTGCGGATGAAAACAGGAACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References