Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 719280..719929 Replicon chromosome
Accession NZ_CP069062
Organism Mycobacterium tuberculosis strain N0069

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag JN151_RS03280 Protein ID WP_003403236.1
Coordinates 719534..719929 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag JN151_RS03275 Protein ID WP_003403235.1
Coordinates 719280..719534 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN151_RS03250 714405..714488 + 84 Protein_644 galactose-1-phosphate uridylyltransferase -
JN151_RS03255 714507..715589 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
JN151_RS03260 715586..716677 + 1092 WP_003900977.1 galactokinase -
JN151_RS03265 717072..718229 + 1158 WP_003903091.1 hypothetical protein -
JN151_RS03270 718240..719187 + 948 WP_003403232.1 DUF732 domain-containing protein -
JN151_RS03275 719280..719534 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
JN151_RS03280 719534..719929 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
JN151_RS03285 720023..720763 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
JN151_RS03290 720895..721155 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN151_RS03295 721152..721559 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
JN151_RS03300 721631..722782 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
JN151_RS03305 722875..724602 - 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T188872 WP_003403236.1 NZ_CP069062:719534-719929 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T188872 NZ_CP090589:2899433-2899717 [Pectobacterium aroidearum]
ATGGAAATTAAATGGCTGCGTAAAGCCGCGGCCAATTTGGAAGCCGAATACCTCTATATCGCGCAAGACGATCCACAGGC
TGCCAGCCAGTTCGTAGATGAAGTCCAAAGATTAACGGAATTACTACCGCAACAGCCAGCAATGGGAAGGCCAGGCCGTG
TGCCAGGAACGCGTGAGCTGGTGTTAACGCACTATCCCTACATCATCCCCTACCGTGTGAAAGATAATATGCTCCAGATT
CTGCGCATCTTTCATACGCACAGACGTTTACCATCAAAATGGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT188872 WP_003403235.1 NZ_CP069062:719280-719534 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT188872 NZ_CP090589:2899764-2900003 [Pectobacterium aroidearum]
ATGGGTAATGTTACTTTCCGTATCGGTGACGATCTTAAAAAGCGCTCTTATGCAGCGCTTAAGAAACTGGGTATTACGCC
TTCTGAAGCATTTCGCCTCACGTTGGAATACATTGCTGAAAATGAAAGACTCCCATTTAAACAAAAGTTACTCAATGATG
AAGACGTAGAATTAGTTGAAGTTGTCCGTGAACGTCTTCGCAACCCCAAACCAGTACGCGTGACGCTGGATGATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References