Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 719280..719929 | Replicon | chromosome |
Accession | NZ_CP069062 | ||
Organism | Mycobacterium tuberculosis strain N0069 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P67241 |
Locus tag | JN151_RS03280 | Protein ID | WP_003403236.1 |
Coordinates | 719534..719929 (+) | Length | 132 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P9WJ34 |
Locus tag | JN151_RS03275 | Protein ID | WP_003403235.1 |
Coordinates | 719280..719534 (+) | Length | 85 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JN151_RS03250 | 714405..714488 | + | 84 | Protein_644 | galactose-1-phosphate uridylyltransferase | - |
JN151_RS03255 | 714507..715589 | + | 1083 | WP_031652152.1 | galactose-1-phosphate uridylyltransferase | - |
JN151_RS03260 | 715586..716677 | + | 1092 | WP_003900977.1 | galactokinase | - |
JN151_RS03265 | 717072..718229 | + | 1158 | WP_003903091.1 | hypothetical protein | - |
JN151_RS03270 | 718240..719187 | + | 948 | WP_003403232.1 | DUF732 domain-containing protein | - |
JN151_RS03275 | 719280..719534 | + | 255 | WP_003403235.1 | type II toxin-antitoxin system antitoxin VapB30 | Antitoxin |
JN151_RS03280 | 719534..719929 | + | 396 | WP_003403236.1 | type II toxin-antitoxin system toxin ribonuclease C30 | Toxin |
JN151_RS03285 | 720023..720763 | - | 741 | WP_003403239.1 | TVP38/TMEM64 family protein | - |
JN151_RS03290 | 720895..721155 | + | 261 | WP_003403244.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
JN151_RS03295 | 721152..721559 | + | 408 | WP_003403246.1 | type II toxin-antitoxin system VapC family toxin | - |
JN151_RS03300 | 721631..722782 | - | 1152 | WP_003403248.1 | FIST N-terminal domain-containing protein | - |
JN151_RS03305 | 722875..724602 | - | 1728 | WP_003900979.1 | exodeoxyribonuclease V subunit alpha | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14250.04 Da Isoelectric Point: 4.7475
>T188872 WP_003403236.1 NZ_CP069062:719534-719929 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP
Download Length: 396 bp
>T188872 NZ_CP090589:2899433-2899717 [Pectobacterium aroidearum]
ATGGAAATTAAATGGCTGCGTAAAGCCGCGGCCAATTTGGAAGCCGAATACCTCTATATCGCGCAAGACGATCCACAGGC
TGCCAGCCAGTTCGTAGATGAAGTCCAAAGATTAACGGAATTACTACCGCAACAGCCAGCAATGGGAAGGCCAGGCCGTG
TGCCAGGAACGCGTGAGCTGGTGTTAACGCACTATCCCTACATCATCCCCTACCGTGTGAAAGATAATATGCTCCAGATT
CTGCGCATCTTTCATACGCACAGACGTTTACCATCAAAATGGTGA
ATGGAAATTAAATGGCTGCGTAAAGCCGCGGCCAATTTGGAAGCCGAATACCTCTATATCGCGCAAGACGATCCACAGGC
TGCCAGCCAGTTCGTAGATGAAGTCCAAAGATTAACGGAATTACTACCGCAACAGCCAGCAATGGGAAGGCCAGGCCGTG
TGCCAGGAACGCGTGAGCTGGTGTTAACGCACTATCCCTACATCATCCCCTACCGTGTGAAAGATAATATGCTCCAGATT
CTGCGCATCTTTCATACGCACAGACGTTTACCATCAAAATGGTGA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9139.52 Da Isoelectric Point: 9.2702
>AT188872 WP_003403235.1 NZ_CP069062:719280-719534 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA
Download Length: 255 bp
>AT188872 NZ_CP090589:2899764-2900003 [Pectobacterium aroidearum]
ATGGGTAATGTTACTTTCCGTATCGGTGACGATCTTAAAAAGCGCTCTTATGCAGCGCTTAAGAAACTGGGTATTACGCC
TTCTGAAGCATTTCGCCTCACGTTGGAATACATTGCTGAAAATGAAAGACTCCCATTTAAACAAAAGTTACTCAATGATG
AAGACGTAGAATTAGTTGAAGTTGTCCGTGAACGTCTTCGCAACCCCAAACCAGTACGCGTGACGCTGGATGATCTTTAA
ATGGGTAATGTTACTTTCCGTATCGGTGACGATCTTAAAAAGCGCTCTTATGCAGCGCTTAAGAAACTGGGTATTACGCC
TTCTGAAGCATTTCGCCTCACGTTGGAATACATTGCTGAAAATGAAAGACTCCCATTTAAACAAAAGTTACTCAATGATG
AAGACGTAGAATTAGTTGAAGTTGTCCGTGAACGTCTTCGCAACCCCAAACCAGTACGCGTGACGCTGGATGATCTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 4XGR | |
PDB | 4XGQ |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BSC2 |