Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 713651..714276 Replicon chromosome
Accession NZ_CP069062
Organism Mycobacterium tuberculosis strain N0069

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag JN151_RS03245 Protein ID WP_003403218.1
Coordinates 713875..714276 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag JN151_RS03240 Protein ID WP_003403213.1
Coordinates 713651..713878 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN151_RS03215 708830..709051 - 222 WP_003898525.1 DUF4926 domain-containing protein -
JN151_RS03220 709193..709798 + 606 WP_003898526.1 hypothetical protein -
JN151_RS03225 709817..712384 - 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
JN151_RS03230 712468..713217 + 750 WP_003898528.1 hypothetical protein -
JN151_RS03235 713214..713456 + 243 WP_003403210.1 hypothetical protein -
JN151_RS03240 713651..713878 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
JN151_RS03245 713875..714276 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
JN151_RS03250 714405..714488 + 84 Protein_644 galactose-1-phosphate uridylyltransferase -
JN151_RS03255 714507..715589 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
JN151_RS03260 715586..716677 + 1092 WP_003900977.1 galactokinase -
JN151_RS03265 717072..718229 + 1158 WP_003903091.1 hypothetical protein -
JN151_RS03270 718240..719187 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T188871 WP_003403218.1 NZ_CP069062:713875-714276 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T188871 NZ_CP090589:1799908-1800228 [Pectobacterium aroidearum]
ATGCAAACATCACCTGCAATCCCGCCACGGGAGGATAACCCCTGTGCGTCACCTGTAGCCGTCTGGCAACAACTGCTGAC
CTACCTGCTGGAAAAGCACTACGGCCTGACGCTGAACGACACACCGTTCTGTGAGGAAAATGTCATTCAGGCGCATATCG
ATGCTGGCGTCACGCTGGTCAATGCCGTGAACTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGCTCGCGACGGTTTT
AACTGGCAGGAGCAATCGCCGTTTCTTACCGCTGTTGATATTCTCCGTGCCAGACGTGCTACCGGCTTGCTCAAGGCATA
A

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT188871 WP_003403213.1 NZ_CP069062:713651-713878 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT188871 NZ_CP090589:1799503-1799838 [Pectobacterium aroidearum]
ATGCCATCATCGGATACCCCGGAGTGGGGATTAAAATGTGCCATCACTCGGCGATTCGGAGCCAGACTGGTGCAGGAAGG
TAACCGTCTGCACTATCTGGCAGACCGGGCCAGCATTGTCGGTACGTTTAGCAAAACAGAAGCCCAAAGTCTGGAGCGTT
GTTTCCCTGAGCTAATTGAGCTGTTGGAACAGAAGCTACGCATGGGGGAACTGAATCCCCGTCAGCAGGGGGGTGTCACG
TTGTATTGTAACGAATGGACCTGTGAAGCCGATACGCTGGGCAGTGTTGGCTACGTGTATATTGTTATTTATCCTTCTTC
AGCGGCAACACAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References