Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pezAT/zeta-ParD |
Location | 446655..447666 | Replicon | chromosome |
Accession | NZ_CP069062 | ||
Organism | Mycobacterium tuberculosis strain N0069 |
Toxin (Protein)
Gene name | pezT | Uniprot ID | L7N5R2 |
Locus tag | JN151_RS01930 | Protein ID | WP_003401859.1 |
Coordinates | 446655..447248 (-) | Length | 198 a.a. |
Antitoxin (Protein)
Gene name | pezA | Uniprot ID | O53702 |
Locus tag | JN151_RS01935 | Protein ID | WP_003401860.1 |
Coordinates | 447277..447666 (-) | Length | 130 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JN151_RS01910 | 442304..443686 | + | 1383 | WP_003898415.1 | magnesium transporter | - |
JN151_RS01915 | 443698..444732 | - | 1035 | WP_003401856.1 | class II fructose-bisphosphate aldolase | - |
JN151_RS01920 | 444828..445511 | + | 684 | WP_003401857.1 | VTT domain-containing protein | - |
JN151_RS01925 | 445500..446630 | - | 1131 | WP_003401858.1 | glycoside hydrolase family 76 protein | - |
JN151_RS01930 | 446655..447248 | - | 594 | WP_003401859.1 | zeta toxin family protein | Toxin |
JN151_RS01935 | 447277..447666 | - | 390 | WP_003401860.1 | hypothetical protein | Antitoxin |
JN151_RS01940 | 447747..448958 | - | 1212 | WP_003401861.1 | VWA domain-containing protein | - |
JN151_RS01945 | 448964..449566 | - | 603 | WP_003898417.1 | SRPBCC family protein | - |
JN151_RS01950 | 449580..450476 | - | 897 | WP_003902972.1 | MoxR family ATPase | - |
JN151_RS01955 | 450473..451066 | - | 594 | WP_003401864.1 | NTP transferase domain-containing protein | - |
JN151_RS01960 | 451063..451818 | - | 756 | WP_003401865.1 | XdhC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 198 a.a. Molecular weight: 21344.53 Da Isoelectric Point: 10.5018
>T188865 WP_003401859.1 NZ_CP069062:c447248-446655 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA
Download Length: 594 bp
>T188865 NZ_CP090588:c4500065-4498731 [Pectobacterium aroidearum]
ATGCCTCGAATACAACAGCGTTTAGCAATATGGATGAATGGAATTCAAGTGGGATTCTGGGAAAAGACCAGAGGCGAAGA
TAGGTTGCAATACCTTCCCGAATGGATTGCTGATGAACAGGGAAGACCTTTATCGCTTTCTTTGCTTTTCACCCCCGGTA
ATCAAATTTGGCGCGGCAATGTGGTACGCGACTATTTTGATAATTTATTGCCTGACAGCGAAGGTATACGCAGGCGTTTA
GCAACGCGTTACCACGCTGATAGCCTTGAGCCTTTTGATCTGTTGGCTGAGCTGGGAAGAGACTGTGTTGGTGCGATACA
GTTGCTGAATGGTAATGAGGAGCCTACAGATCTCTTTTCCGTAAAGTATCGCCCGCTTTGTGGCGCAGAGATCGCCGCTA
TATTGCGTAATACAACAGCGGCATTGTTGCCAGGTCGGCAGGATGATACTGACGATTTACGTTTATCGATTGCCGGTGCG
CAGGAGAAAACGGCTTTACTCTGGCATGAAGGGCAATGGTGCTTGCCAGAAGGGAGTACCCCTACGACGCATATTTTCAA
GTTACCACTCGGGCTAGTGGGTAATATGCAAGCGGATATGAGTACGTCGGTTGAAAATGAATGGCTATGTTCTTTGATCC
TTAAGGAATATGGGATTCCTGTCGCAAAAACGCAAATTGCACAGTTTGAAGAGCAGAAGGCACTGGTTGTTGAGCGTTTT
GATAGAAGATGGTCAAGCGATCAGCAATGGATCATTCGCTTGCCACAAGAGGATATGTGTCAGGCTCTGGGTGTTTCCCC
GCTACGAAAATACCAGTCTGATGGTGGTCCGGGGATTTCCGATATTATGGAAATACTGAGTCATTCAGAGCAGGCTGAGC
AGGACAAAGCGCAGTTTTTCAGGGCGCAAATTATTTTCTGGCTGATAGCGGCTACTGATGGGCACGCCAAAAATTTCAGT
ATCGCTATTGAGCCACAAGGTCGCTATCACCTTACGCCACTTTATGATGTTTTATCGGCATGGCCGGTCATTGGTCCGCG
TAATAACCAGATTTCCTGGCAGAAGTGCAAGCTGGCAATGGCTGTTCGGGGTAGCAGTAATTATTACCATCTGTACAGAA
TTCAACGGCGGCATTGGGTCAATCATGGTGAATTAACTGGTCTGGGCAGGCGACAGGTTGAAGCCATGATGGATGATATT
ATATCCAGGACACCTGAGGTTATTGAACGTGTATCTTCGTTGCTGCCTGAGTCATTCCCACCAGAGCTTGCGGAATGTGT
TTTTGACGGTATGCGACAACAGTGTGGTCGGTTACAAGAATTGCAGCGTAAATAG
ATGCCTCGAATACAACAGCGTTTAGCAATATGGATGAATGGAATTCAAGTGGGATTCTGGGAAAAGACCAGAGGCGAAGA
TAGGTTGCAATACCTTCCCGAATGGATTGCTGATGAACAGGGAAGACCTTTATCGCTTTCTTTGCTTTTCACCCCCGGTA
ATCAAATTTGGCGCGGCAATGTGGTACGCGACTATTTTGATAATTTATTGCCTGACAGCGAAGGTATACGCAGGCGTTTA
GCAACGCGTTACCACGCTGATAGCCTTGAGCCTTTTGATCTGTTGGCTGAGCTGGGAAGAGACTGTGTTGGTGCGATACA
GTTGCTGAATGGTAATGAGGAGCCTACAGATCTCTTTTCCGTAAAGTATCGCCCGCTTTGTGGCGCAGAGATCGCCGCTA
TATTGCGTAATACAACAGCGGCATTGTTGCCAGGTCGGCAGGATGATACTGACGATTTACGTTTATCGATTGCCGGTGCG
CAGGAGAAAACGGCTTTACTCTGGCATGAAGGGCAATGGTGCTTGCCAGAAGGGAGTACCCCTACGACGCATATTTTCAA
GTTACCACTCGGGCTAGTGGGTAATATGCAAGCGGATATGAGTACGTCGGTTGAAAATGAATGGCTATGTTCTTTGATCC
TTAAGGAATATGGGATTCCTGTCGCAAAAACGCAAATTGCACAGTTTGAAGAGCAGAAGGCACTGGTTGTTGAGCGTTTT
GATAGAAGATGGTCAAGCGATCAGCAATGGATCATTCGCTTGCCACAAGAGGATATGTGTCAGGCTCTGGGTGTTTCCCC
GCTACGAAAATACCAGTCTGATGGTGGTCCGGGGATTTCCGATATTATGGAAATACTGAGTCATTCAGAGCAGGCTGAGC
AGGACAAAGCGCAGTTTTTCAGGGCGCAAATTATTTTCTGGCTGATAGCGGCTACTGATGGGCACGCCAAAAATTTCAGT
ATCGCTATTGAGCCACAAGGTCGCTATCACCTTACGCCACTTTATGATGTTTTATCGGCATGGCCGGTCATTGGTCCGCG
TAATAACCAGATTTCCTGGCAGAAGTGCAAGCTGGCAATGGCTGTTCGGGGTAGCAGTAATTATTACCATCTGTACAGAA
TTCAACGGCGGCATTGGGTCAATCATGGTGAATTAACTGGTCTGGGCAGGCGACAGGTTGAAGCCATGATGGATGATATT
ATATCCAGGACACCTGAGGTTATTGAACGTGTATCTTCGTTGCTGCCTGAGTCATTCCCACCAGAGCTTGCGGAATGTGT
TTTTGACGGTATGCGACAACAGTGTGGTCGGTTACAAGAATTGCAGCGTAAATAG
Antitoxin
Download Length: 130 a.a. Molecular weight: 13648.21 Da Isoelectric Point: 6.0829
>AT188865 WP_003401860.1 NZ_CP069062:c447666-447277 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP
Download Length: 390 bp
>AT188865 NZ_CP090588:c4500375-4500070 [Pectobacterium aroidearum]
ATGAATACAGTCTATCCGTTGAAAACCTTGAATCAGTTGCGCCCATTGCTGATTGGCTTTCGCAAAGCTAAGGGGCTGAC
GCAAAAAGACGTGTCTGAAAGGTTAGGTGTAACACAGCAAACCTATGCCCGCTTGGAAGCAAACCCCGGCAGTGCCAGTA
TTGAGCGCTTGTTTAAAGTGCTAACTATTCTGGGGGTTGAGGTGGTGCTGTCTTCTGGACCAAGAGTGCATTTCTCTATG
TCATCCTCAACAATGGAAGAGCCAGAAAAGCCAATAGACTCACCCGCCAGACGGGAAAAATGGTGA
ATGAATACAGTCTATCCGTTGAAAACCTTGAATCAGTTGCGCCCATTGCTGATTGGCTTTCGCAAAGCTAAGGGGCTGAC
GCAAAAAGACGTGTCTGAAAGGTTAGGTGTAACACAGCAAACCTATGCCCGCTTGGAAGCAAACCCCGGCAGTGCCAGTA
TTGAGCGCTTGTTTAAAGTGCTAACTATTCTGGGGGTTGAGGTGGTGCTGTCTTCTGGACCAAGAGTGCATTTCTCTATG
TCATCCTCAACAATGGAAGAGCCAGAAAAGCCAATAGACTCACCCGCCAGACGGGAAAAATGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BRU8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BRT0 |