Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 366348..366991 Replicon chromosome
Accession NZ_CP069062
Organism Mycobacterium tuberculosis strain N0069

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag JN151_RS01600 Protein ID WP_003401566.1
Coordinates 366566..366991 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag JN151_RS01595 Protein ID WP_003401563.1
Coordinates 366348..366569 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN151_RS01570 361422..362225 - 804 WP_003401540.1 Stf0 family sulphotransferase -
JN151_RS01575 362235..363632 - 1398 WP_003401544.1 sulfatase -
JN151_RS01580 363811..365631 + 1821 WP_031653699.1 PE family protein -
JN151_RS01585 365774..366001 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
JN151_RS01590 365998..366300 + 303 WP_003401560.1 toxin-antitoxin system toxin -
JN151_RS01595 366348..366569 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
JN151_RS01600 366566..366991 + 426 WP_003401566.1 PIN domain nuclease Toxin
JN151_RS01605 367127..367759 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
JN151_RS01610 367756..368664 + 909 WP_003900117.1 protochlorophyllide reductase -
JN151_RS01615 368672..369262 - 591 WP_229298012.1 hypothetical protein -
JN151_RS01620 369255..369305 - 51 Protein_320 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T188864 WP_003401566.1 NZ_CP069062:366566-366991 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T188864 NZ_CP090588:4451988-4452242 [Pectobacterium aroidearum]
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTACCTGTACTGGCAGGACATCGATAAGCGGATGGTCAAAAAAAT
CAATGAATTAATAAAAGAAACGCGCAGAACACCTTTTGAGGGAAAAGGAAAACCAGAGCCACTTAAACATAATCTTGCTG
GTTTCTGGTCGCGCCGTATCACCGAAGAACATCGTCTGGTTTATGCCATCACCGATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT188864 WP_003401563.1 NZ_CP069062:366348-366569 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT188864 NZ_CP090588:4451740-4451991 [Pectobacterium aroidearum]
ATGCGTACAATTAGCTACAGTGAAGCCCGACAAAATCTATCGGCGACCATGATGAAAACGGTCGAAGACCGTGCTCCCAT
TCTTATCACTCGACAGAATGGTGAAGCCTGCGTGCTCATGTCTTTGGAAGAATATAACTCTCTAGAGGAGACCGCGTATT
TACTGCGTTCACCAGCAAATGCAAAAAGACTGATGAACTCAATCGAGAGCCTTAAAGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References