Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Rv0299-vapB/- |
Location | 365998..366569 | Replicon | chromosome |
Accession | NZ_CP069062 | ||
Organism | Mycobacterium tuberculosis strain N0069 |
Toxin (Protein)
Gene name | Rv0299 | Uniprot ID | - |
Locus tag | JN151_RS01590 | Protein ID | WP_003401560.1 |
Coordinates | 365998..366300 (+) | Length | 101 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | O07227 |
Locus tag | JN151_RS01595 | Protein ID | WP_003401563.1 |
Coordinates | 366348..366569 (+) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JN151_RS01570 | 361422..362225 | - | 804 | WP_003401540.1 | Stf0 family sulphotransferase | - |
JN151_RS01575 | 362235..363632 | - | 1398 | WP_003401544.1 | sulfatase | - |
JN151_RS01580 | 363811..365631 | + | 1821 | WP_031653699.1 | PE family protein | - |
JN151_RS01585 | 365774..366001 | + | 228 | WP_003401555.1 | ribbon-helix-helix protein, CopG family | - |
JN151_RS01590 | 365998..366300 | + | 303 | WP_003401560.1 | toxin-antitoxin system toxin | Toxin |
JN151_RS01595 | 366348..366569 | + | 222 | WP_003401563.1 | type II toxin-antitoxin system antitoxin VapB2 | Antitoxin |
JN151_RS01600 | 366566..366991 | + | 426 | WP_003401566.1 | PIN domain nuclease | - |
JN151_RS01605 | 367127..367759 | + | 633 | WP_003401571.1 | TetR/AcrR family transcriptional regulator | - |
JN151_RS01610 | 367756..368664 | + | 909 | WP_003900117.1 | protochlorophyllide reductase | - |
JN151_RS01615 | 368672..369262 | - | 591 | WP_229298012.1 | hypothetical protein | - |
JN151_RS01620 | 369255..369305 | - | 51 | Protein_320 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 10442.16 Da Isoelectric Point: 4.9609
>T188863 WP_003401560.1 NZ_CP069062:365998-366300 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC
Download Length: 303 bp
>T188863 NZ_CP090588:4451740-4451991 [Pectobacterium aroidearum]
ATGCGTACAATTAGCTACAGTGAAGCCCGACAAAATCTATCGGCGACCATGATGAAAACGGTCGAAGACCGTGCTCCCAT
TCTTATCACTCGACAGAATGGTGAAGCCTGCGTGCTCATGTCTTTGGAAGAATATAACTCTCTAGAGGAGACCGCGTATT
TACTGCGTTCACCAGCAAATGCAAAAAGACTGATGAACTCAATCGAGAGCCTTAAAGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA
ATGCGTACAATTAGCTACAGTGAAGCCCGACAAAATCTATCGGCGACCATGATGAAAACGGTCGAAGACCGTGCTCCCAT
TCTTATCACTCGACAGAATGGTGAAGCCTGCGTGCTCATGTCTTTGGAAGAATATAACTCTCTAGAGGAGACCGCGTATT
TACTGCGTTCACCAGCAAATGCAAAAAGACTGATGAACTCAATCGAGAGCCTTAAAGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8088.31 Da Isoelectric Point: 10.7177
>AT188863 WP_003401563.1 NZ_CP069062:366348-366569 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR
Download Length: 222 bp
>AT188863 NZ_CP090588:4451988-4452242 [Pectobacterium aroidearum]
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTACCTGTACTGGCAGGACATCGATAAGCGGATGGTCAAAAAAAT
CAATGAATTAATAAAAGAAACGCGCAGAACACCTTTTGAGGGAAAAGGAAAACCAGAGCCACTTAAACATAATCTTGCTG
GTTTCTGGTCGCGCCGTATCACCGAAGAACATCGTCTGGTTTATGCCATCACCGATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTACCTGTACTGGCAGGACATCGATAAGCGGATGGTCAAAAAAAT
CAATGAATTAATAAAAGAAACGCGCAGAACACCTTTTGAGGGAAAAGGAAAACCAGAGCCACTTAAACATAATCTTGCTG
GTTTCTGGTCGCGCCGTATCACCGAAGAACATCGTCTGGTTTATGCCATCACCGATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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