188860

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 539596..540232 Replicon chromosome
Accession NZ_CP069061
Organism Bacillus safensis strain F6

Toxin (Protein)


Gene name mazF Uniprot ID A0A0P7G713
Locus tag JNE45_RS02600 Protein ID WP_024425388.1
Coordinates 539882..540232 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag JNE45_RS02595 Protein ID WP_003214273.1
Coordinates 539596..539877 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNE45_RS02575 535740..536345 - 606 WP_203129312.1 rhomboid family intramembrane serine protease -
JNE45_RS02580 536440..536805 + 366 WP_203129313.1 holo-ACP synthase -
JNE45_RS02585 536966..537982 + 1017 WP_203129314.1 outer membrane lipoprotein carrier protein LolA -
JNE45_RS02590 538122..539303 + 1182 WP_203129315.1 alanine racemase -
JNE45_RS02595 539596..539877 + 282 WP_003214273.1 hypothetical protein Antitoxin
JNE45_RS02600 539882..540232 + 351 WP_024425388.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
JNE45_RS02605 540347..541177 + 831 WP_203129316.1 RsbT co-antagonist protein RsbRA -
JNE45_RS02610 541182..541550 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
JNE45_RS02615 541553..541954 + 402 WP_203129317.1 anti-sigma regulatory factor -
JNE45_RS02620 541965..542972 + 1008 WP_203129318.1 PP2C family protein-serine/threonine phosphatase -
JNE45_RS02625 543034..543363 + 330 WP_203129319.1 anti-sigma factor antagonist -
JNE45_RS02630 543360..543848 + 489 WP_203129320.1 anti-sigma B factor RsbW -
JNE45_RS02635 543814..544602 + 789 WP_203129321.1 RNA polymerase sigma factor SigB -
JNE45_RS02640 544602..545201 + 600 WP_203129322.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8891

>T188860 WP_024425388.1 NZ_CP069061:539882-540232 [Bacillus safensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

>T188860 NZ_CP090588:3915060-3915365 [Pectobacterium aroidearum]
ATGCAATTCATTGTTTATCAATACAAACGTGCCAGCCACTACAAAATGTTTGTTGATGTGCAGAGTGATATTGTCGAGAC
ACCGAAGCGGCGCATGGTCATTCCGCTTATCGAAACACATCACCTGTCTGAGAAAGTGAATAAAACGCTGTTCCCTCAGA
TCCACATCGAAGGCGAAGATTATCGACTGATGACCACTGAGCTGTCTAGTGTTCCTGTTGAGGTTATTGGTGAGGCTATC
GTGGATCTTGGAGACTATGCCGATGAGATCAAGGATGCTATTAATCTTATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT188860 WP_003214273.1 NZ_CP069061:539596-539877 [Bacillus safensis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp

>AT188860 NZ_CP090588:3914839-3915057 [Pectobacterium aroidearum]
ATGAAACACCGCGTCAGCGTTACCGTGGACAAAGACAATTACCAGGTTCTGAGTGCTGCCGGAGTCAATATTTCCGGGCT
AGTGAATGATGCTATTGGCAAAGAAGCCCGCCGCATCAAAGCTGAGGAATGGAAGAAGGAAAACCGCGAAGGGATGGAAG
AAGTCGCCCGATTTATCGCACAGCATGGCTCCTTTGCGGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7G713

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References