Detailed information of TA system TA188859

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 982104..983571
• Replicon: chromosome
• Accession: NZ_CP069057
• Organism: Mycoplasma bovis strain Mb160

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: A0A2N8U3K6
• Locus tag: JN825_RS04180
• Protein ID: WP_014829995.1
• Coordinates: 982104..982964 (-)
• Length: 287 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: Q934C3
• Locus tag: JN825_RS04185
• Protein ID: WP_013456322.1
• Coordinates: 982957..983571 (-)
• Length: 205 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN825_RS04155	978437..979252	+	816	Protein_793	variable surface lipoprotein	-
JN825_RS04160	979419..979676	+	258	Protein_794	variable surface lipoprotein	-
JN825_RS04165	980442..980549	+	108	Protein_795	variable surface lipoprotein	-
JN825_RS04170	980546..981076	-	531	Protein_796	collagen-like protein	-
JN825_RS04175	981694..981984	-	291	Protein_797	variable surface lipoprotein	-
JN825_RS04180	982104..982964	-	861	WP_014829995.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JN825_RS04185	982957..983571	-	615	WP_013456322.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
JN825_RS04190	983754..983861	+	108	Protein_800	variable surface lipoprotein	-
JN825_RS04195	984621..985277	-	657	WP_203024992.1	variable surface lipoprotein	-
JN825_RS04200	986219..986332	-	114	Protein_802	variable surface lipoprotein	-
JN825_RS04205	986508..987308	-	801	WP_203025052.1	hypothetical protein	-
JN825_RS04210	987346..987666	-	321	Protein_804	variable surface lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	975423..990354	14931

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-234)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (13-59)

Sequences

Toxin

Protein

• Length: 287 a.a.
• Molecular weight: 33280.36 Da
• Isoelectric Point: 7.7731

>T188859 WP_014829995.1 NZ_CP069057:c982964-982104 [Mycoplasma bovis]
MNKNKLISLCHKTADQNNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKVNELTNND

Nucleotide

• Length: 861 bp

>T188859 NZ_CP090588:3684324-3684527 [Pectobacterium aroidearum]
ATGAAAAAAATCGACTATTTGATGCGTTTGCGTAAATGCACAACCATTGACACTCTCGAACGCGTTATTGAAAAAAACAA
GTATGAACTCTCTAATGATGAACTGGAGATGTTCTTTTCCGCAGCCGATCATCGTCTGGCAGAACTGACGATGAACAAAC
TTTACGACAAAGTTCCTACCGCAGTATGGCGATACGTCCGTTAA

Antitoxin

Protein

• Length: 205 a.a.
• Molecular weight: 24143.83 Da
• Isoelectric Point: 9.7617

>AT188859 WP_013456322.1 NZ_CP069057:c983571-982957 [Mycoplasma bovis]
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE

Nucleotide

• Length: 615 bp

>AT188859 NZ_CP090588:3683902-3684270 [Pectobacterium aroidearum]
ATGGATGAGTACACACCAAAACATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTGTGTGACGAAAGCATAGC
AACGTTAGGCGATAGCAGCCACGGCTGGGTCAATGATCCAACATCTGCGATCAATCTCCAATTAAATGAACTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTTTCAGAGCAGGTTGAAAAGTATTTG
GATGATACTTACGTCTTGTTTAGCAACTATGGGATTAATGATGCTGAACTGCGGCGCTGGCAGAAGTCCAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACGTCTGTACGCCTGCTAAAACTTAA

Structures

Toxin

• AlphaFold DB: A0A2N8U3K6

Antitoxin

• AlphaFold DB: Q934C3