Detailed information of TA system TA188851

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5099474..5101155
• Replicon: chromosome
• Accession: NZ_CP069046
• Organism: Klebsiella pneumoniae strain 33Kpn22

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: W8V1Q6
• Locus tag: IFY68_RS25060
• Protein ID: WP_002885155.1
• Coordinates: 5099474..5100391 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: IFY68_RS25065
• Protein ID: WP_203162937.1
• Coordinates: 5100397..5101155 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IFY68_RS25040	5094780..5096300	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
IFY68_RS25045	5096297..5097295	+	999	WP_002885172.1	ribose ABC transporter permease	-
IFY68_RS25050	5097326..5098267	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
IFY68_RS25055	5098342..5099349	+	1008	WP_004151731.1	carbohydrate kinase family protein	-
IFY68_RS25060	5099474..5100391	-	918	WP_002885155.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
IFY68_RS25065	5100397..5101155	-	759	WP_203162937.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
IFY68_RS25070	5101241..5101969	-	729	WP_002885152.1	response regulator transcription factor	-
IFY68_RS25075	5102242..5104389	+	2148	WP_077598858.1	formate dehydrogenase subunit alpha	-
IFY68_RS25080	5104619..5105305	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (2-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34687.15 Da
• Isoelectric Point: 5.4707

>T188851 WP_002885155.1 NZ_CP069046:c5100391-5099474 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T188851 NZ_CP090587:c4581688-4581401 [Pectobacterium aroidearum]
ATGACCTATAAGTTAAAATTTGTGCCTTCTGCAATGAAGGAATGGAAAAAGTTAGGGCATCCTGTCAGGGAACAATTCAA
AAAAAAGCTAGTTGAGCGTTTAGAAAATCCTCGTGTTCCTTCAGCCCAGCTTCATGGTCGTAAAGACCAGTATAAAATTA
AGCTGAAGTCTGCTGGTTACAGGCTGGTATATTTGGTTCAGGATGAGACCATTACGGTGATGATCATGGGGGTTGGAAAG
CGCGAAGGTAGTCAGGTTTATTTTGATACTAAAGGCCGCTCTGCTTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28592.98 Da
• Isoelectric Point: 10.0870

>AT188851 WP_203162937.1 NZ_CP069046:c5101155-5100397 [Klebsiella pneumoniae]
MVTKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT188851 NZ_CP090587:c4581932-4581678 [Pectobacterium aroidearum]
ATGGCTTTCAATATCCTAACTAACACAGCGGCCAGCATCACTGAACTGAAACGCGACCCAATGGGGACAGTACGGGCTGC
TGAAGGTGAGACTATCGCTATACTGAACCGGAATGAGCCTGCGTTCTATTGTGTGCCTCCTGCCATGTTCGCTTATTTAA
TGGAATTGGCTGAAGATGCAGAATTGGGGCGTACTGTTGATGATCGTATGTCAGAGTTAGCTGACGCGGAAGAGATTTCG
CTCGATGACCTATAA

Structures

Toxin

• AlphaFold DB: A0A0H3GH11