Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2902238..2903826 Replicon chromosome
Accession NZ_CP069046
Organism Klebsiella pneumoniae strain 33Kpn22

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag IFY68_RS14330 Protein ID WP_002904792.1
Coordinates 2902238..2903560 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag IFY68_RS14335 Protein ID WP_002904790.1
Coordinates 2903560..2903826 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFY68_RS14315 2897294..2899795 + 2502 WP_004151634.1 fimbrial biogenesis outer membrane usher protein -
IFY68_RS14320 2899783..2900787 + 1005 WP_002904798.1 type 1 fimbrial protein -
IFY68_RS14325 2900929..2902221 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
IFY68_RS14330 2902238..2903560 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
IFY68_RS14335 2903560..2903826 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
IFY68_RS14340 2904092..2904418 - 327 WP_002904788.1 hydroxyisourate hydrolase -
IFY68_RS14345 2904415..2904915 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
IFY68_RS14350 2904893..2906272 - 1380 WP_002904785.1 purine permease -
IFY68_RS14355 2906618..2907772 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
IFY68_RS14360 2907753..2908676 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T188847 WP_002904792.1 NZ_CP069046:c2903560-2902238 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T188847 NZ_CP090587:c4359536-4359048 [Pectobacterium aroidearum]
ATGATCTCTGCCCCTGAGCCAGTCCACGCCGAACATGTACTATCCTCATTCTGTTGTGGCGTGGAGTCTATGGATAACTG
GCTGAAACAGCGGGCGATAAAAAATCAGGTATCTGGCGCATCACGGACTTTCGTCAGTTGCGGTGACTCAAAGGTGCTGG
CGTATTACTCATTGGCTTCCAGTGCCGTAGCAACGAATGCCGCTCCCGGACGCTTTCGCCGCAATATGCCTGACCCGATT
CCAGTTGTGGTTCTGGGACGTCTGGCAGTAGATAAATCATTGCATGGTCAGGGTGTTGGCCGTGCTCTGGTACGTGACGC
TGGGCTAAGGGTGATTCAGGTCGCTGATACTATCGGTATTCGTGGGATTTTGGTTCATGCGTTGTCTGATGAGGCGAGGG
AATTTTACCTGCGGGTGGGGTTTGAGCCTTCACCGATTGACCCTATGATGTTGATGATGACGTTAGGGGATTTGATGGGG
AGTGTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT188847 WP_002904790.1 NZ_CP069046:c2903826-2903560 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT188847 NZ_CP090587:c4359826-4359533 [Pectobacterium aroidearum]
ATGCCAGTGAGGAACAGCGTTTCTGTTAAACGCGAAACATTGAATTTACGCATCAAACCCGCAGAACGGGATCTGATTGA
TCGTGCAGCGAAGGCCAGAGGAAAAAATCGCACTGATTTTGTCCTTGAAGCTGCTCGCGCTGCCGCAGAGGAAGCGTTGA
TCGAACAACGCATCATCATGGCAGATCCCGACGCTTATCAGGAATTCCTTGCCCGTTTGGATCAGGCTCCTGCACCAAAT
GCCGCGCTGCGTAAAACCATGCAAACACTTGCACCGTGGGAGCAGAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References