Detailed information of TA system TA188833

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 128530..129560
• Replicon: chromosome
• Accession: NZ_CP069004
• Organism: Sulfitobacter mediterraneus strain SC1-11

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: JNX03_RS00570
• Protein ID: WP_203210568.1
• Coordinates: 128985..129560 (+)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: JNX03_RS00565
• Protein ID: WP_203212077.1
• Coordinates: 128530..128988 (+)
• Length: 153 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNX03_RS00540	123538..125208	+	1671	WP_203210564.1	urocanate hydratase	-
JNX03_RS00545	125400..126437	+	1038	WP_203210565.1	aromatic ring-hydroxylating dioxygenase subunit alpha	-
JNX03_RS00550	126441..126881	-	441	WP_203212076.1	hypothetical protein	-
JNX03_RS00555	127473..128336	+	864	WP_203210566.1	hypothetical protein	-
JNX03_RS00560	128333..128509	+	177	WP_203210567.1	hypothetical protein	-
JNX03_RS00565	128530..128988	+	459	WP_203212077.1	helix-turn-helix domain-containing protein	Antitoxin
JNX03_RS00570	128985..129560	+	576	WP_203210568.1	PIN domain-containing protein	Toxin
JNX03_RS00575	129615..130211	-	597	WP_203210569.1	hypothetical protein	-
JNX03_RS00580	130458..130712	+	255	WP_203212078.1	helix-turn-helix domain-containing protein	-
JNX03_RS00585	130981..131283	+	303	WP_058260762.1	helix-turn-helix domain-containing protein	-
JNX03_RS00590	131276..132496	+	1221	WP_203210570.1	type II toxin-antitoxin system HipA family toxin	-
JNX03_RS00595	132804..133001	+	198	WP_035262952.1	hypothetical protein	-
JNX03_RS00600	133265..134551	-	1287	WP_203210571.1	calmodulin-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	127176..184406	57230

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (11-115)

Antitoxin

• Helix-turn-helix domain, group 17 (83-131)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21087.12 Da
• Isoelectric Point: 4.4836

>T188833 WP_203210568.1 NZ_CP069004:128985-129560 [Sulfitobacter mediterraneus]
MSDYADRFTALIDANVLACAMRRNIILSLAEAGFFRPRWSDRIMDETAGAIAKITKGGADTNKQRSAMERAFPEACVTGY
AGLEAGLELPDPDDRHVLAAAITTSAQVIVTENLKDFPSEALVPFDIDAISADEFISDAIELDPLAAVVALRKMRERFKN
PDMDAEALLQRIKARKLFQTAEILHEYVELL

Nucleotide

• Length: 576 bp

>T188833 NZ_CP090575:956824-957003 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin

Protein

• Length: 153 a.a.
• Molecular weight: 16874.35 Da
• Isoelectric Point: 4.9003

>AT188833 WP_203212077.1 NZ_CP069004:128530-128988 [Sulfitobacter mediterraneus]
MQAKEAFAERLPDQVEIENADSLRRILASQVNGDEAVELSLALGKKQIEPVTLAPALAASLMELLRLVSSGRGFRMIPVD
AELTTQQAADLLNVSRPHLVKLLEEGEIAFFKTGRHRRVKAADLFEYKKKRDSDRSDALSDLAAMDMENDLL

Nucleotide

• Length: 459 bp

>AT188833 NZ_CP090575:956201-956800 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAATTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA