Detailed information of TA system TA188832

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 22373..22934
• Replicon: plasmid P1
• Accession: NZ_CP068999
• Organism: Sulfitobacter mediterraneus strain SC7-37

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JNX02_RS18055
• Protein ID: WP_203199970.1
• Coordinates: 22659..22934 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JNX02_RS18050
• Protein ID: WP_203199969.1
• Coordinates: 22373..22672 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNX02_RS18025	17649..18233	+	585	WP_203199964.1	YdeI/OmpD-associated family protein	-
JNX02_RS18030	18417..18806	+	390	WP_203199965.1	DUF3768 domain-containing protein	-
JNX02_RS18035	18964..20946	+	1983	WP_203199966.1	ParB/RepB/Spo0J family partition protein	-
JNX02_RS18040	21021..21614	+	594	WP_203199967.1	regulator	-
JNX02_RS18045	21614..22270	+	657	WP_203199968.1	hypothetical protein	-
JNX02_RS18050	22373..22672	+	300	WP_203199969.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JNX02_RS18055	22659..22934	+	276	WP_203199970.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JNX02_RS18060	23042..27304	+	4263	WP_203199971.1	strawberry notch family protein	-
JNX02_RS18065	27426..27812	+	387	WP_043872253.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..102150	102150

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-54)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10379.91 Da
• Isoelectric Point: 4.4217

>T188832 WP_203199970.1 NZ_CP068999:22659-22934 [Sulfitobacter mediterraneus]
MPNLEWKATAIADLLAIIDYISDDNPDAAQVLKDEIEQKTSLLPERPQMYRAGRVDGTREMVVRPNYIVVYAESPEMVTI
LRVLHAAQQWP

Nucleotide

• Length: 276 bp

>T188832 NZ_CP090575:793149-793511 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10478.91 Da
• Isoelectric Point: 5.6448

>AT188832 WP_203199969.1 NZ_CP068999:22373-22672 [Sulfitobacter mediterraneus]
MPAQTSMLHVRVDDQLKAQASDALAGVGLTLSDAVRILLTRVAAEGGLPAGLTADPDAYDAWFRAKVQEALDDPRPTTPH
SKAMQDAQALIDGKRLAKS

Nucleotide

• Length: 300 bp

>AT188832 NZ_CP090575:792982-793152 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA