Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | spoIISABC/SpoIISA-SpoIISB |
Location | 1428881..1429800 | Replicon | chromosome |
Accession | NZ_CP068988 | ||
Organism | Bacillus paralicheniformis strain SUBG0010 |
Toxin (Protein)
Gene name | spoIISA | Uniprot ID | A0A6I7TYV7 |
Locus tag | DI291_RS07240 | Protein ID | WP_023856735.1 |
Coordinates | 1429054..1429800 (-) | Length | 249 a.a. |
Antitoxin (Protein)
Gene name | spoIISB | Uniprot ID | A0A6I7TM13 |
Locus tag | DI291_RS07235 | Protein ID | WP_023856734.1 |
Coordinates | 1428881..1429054 (-) | Length | 58 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DI291_RS07215 | 1424306..1425403 | + | 1098 | WP_023856730.1 | mannonate dehydratase | - |
DI291_RS07220 | 1425379..1426227 | + | 849 | WP_023856787.1 | SDR family oxidoreductase | - |
DI291_RS07225 | 1426253..1427266 | + | 1014 | WP_128822277.1 | zinc-binding alcohol dehydrogenase family protein | - |
DI291_RS07230 | 1427318..1428589 | + | 1272 | WP_023856732.1 | MFS transporter | - |
DI291_RS07235 | 1428881..1429054 | - | 174 | WP_023856734.1 | type II toxin-antitoxin system SpoIISB family antitoxin | Antitoxin |
DI291_RS07240 | 1429054..1429800 | - | 747 | WP_023856735.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
DI291_RS07245 | 1429910..1430908 | - | 999 | WP_023856736.1 | inorganic phosphate transporter | - |
DI291_RS07250 | 1430921..1431538 | - | 618 | WP_023856737.1 | DUF47 domain-containing protein | - |
DI291_RS07255 | 1431871..1433628 | + | 1758 | WP_025811589.1 | gamma-glutamyltransferase | - |
DI291_RS07260 | 1433763..1434407 | + | 645 | WP_003180888.1 | YesL family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 249 a.a. Molecular weight: 29421.87 Da Isoelectric Point: 4.6015
>T188828 WP_023856735.1 NZ_CP068988:c1429800-1429054 [Bacillus paralicheniformis]
MLLFYQFLVWLIVLALALYVAAVWRFEKKLTEKTVAIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGNIEAYAEGIEKLIKRFAEKMNISAAL
CEYNSEESKDHLLEHMENRFDVQEKLERKDVYYEENGKMVLIPFSIHDFDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PNEEDGDD
MLLFYQFLVWLIVLALALYVAAVWRFEKKLTEKTVAIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGNIEAYAEGIEKLIKRFAEKMNISAAL
CEYNSEESKDHLLEHMENRFDVQEKLERKDVYYEENGKMVLIPFSIHDFDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PNEEDGDD
Download Length: 747 bp
>T188828 NZ_CP090573:10358-10639 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA
Antitoxin
Download Length: 58 a.a. Molecular weight: 6897.99 Da Isoelectric Point: 10.8356
>AT188828 WP_023856734.1 NZ_CP068988:c1429054-1428881 [Bacillus paralicheniformis]
MEPAFQQDHESAKKRLAFKMFKKQSKTNIAKYEVSPHTERIFRQNERLIGEYKRKKA
MEPAFQQDHESAKKRLAFKMFKKQSKTNIAKYEVSPHTERIFRQNERLIGEYKRKKA
Download Length: 174 bp
>AT188828 NZ_CP090573:10117-10368 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6I7TYV7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6I7TM13 |