Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1428881..1429800 Replicon chromosome
Accession NZ_CP068988
Organism Bacillus paralicheniformis strain SUBG0010

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A6I7TYV7
Locus tag DI291_RS07240 Protein ID WP_023856735.1
Coordinates 1429054..1429800 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A6I7TM13
Locus tag DI291_RS07235 Protein ID WP_023856734.1
Coordinates 1428881..1429054 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DI291_RS07215 1424306..1425403 + 1098 WP_023856730.1 mannonate dehydratase -
DI291_RS07220 1425379..1426227 + 849 WP_023856787.1 SDR family oxidoreductase -
DI291_RS07225 1426253..1427266 + 1014 WP_128822277.1 zinc-binding alcohol dehydrogenase family protein -
DI291_RS07230 1427318..1428589 + 1272 WP_023856732.1 MFS transporter -
DI291_RS07235 1428881..1429054 - 174 WP_023856734.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
DI291_RS07240 1429054..1429800 - 747 WP_023856735.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
DI291_RS07245 1429910..1430908 - 999 WP_023856736.1 inorganic phosphate transporter -
DI291_RS07250 1430921..1431538 - 618 WP_023856737.1 DUF47 domain-containing protein -
DI291_RS07255 1431871..1433628 + 1758 WP_025811589.1 gamma-glutamyltransferase -
DI291_RS07260 1433763..1434407 + 645 WP_003180888.1 YesL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-57)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29421.87 Da        Isoelectric Point: 4.6015

>T188828 WP_023856735.1 NZ_CP068988:c1429800-1429054 [Bacillus paralicheniformis]
MLLFYQFLVWLIVLALALYVAAVWRFEKKLTEKTVAIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGNIEAYAEGIEKLIKRFAEKMNISAAL
CEYNSEESKDHLLEHMENRFDVQEKLERKDVYYEENGKMVLIPFSIHDFDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PNEEDGDD

Download         Length: 747 bp

>T188828 NZ_CP090573:10358-10639 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6897.99 Da        Isoelectric Point: 10.8356

>AT188828 WP_023856734.1 NZ_CP068988:c1429054-1428881 [Bacillus paralicheniformis]
MEPAFQQDHESAKKRLAFKMFKKQSKTNIAKYEVSPHTERIFRQNERLIGEYKRKKA

Download         Length: 174 bp

>AT188828 NZ_CP090573:10117-10368 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7TYV7

Antitoxin

Source ID Structure
AlphaFold DB A0A6I7TM13

References