Detailed information of TA system TA188826

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4340824..4341446
• Replicon: chromosome
• Accession: NZ_CP068986
• Organism: Pseudomonas sp. 15A4

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: JN403_RS19145
• Protein ID: WP_122534666.1
• Coordinates: 4340824..4341003 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: JN403_RS19150
• Protein ID: WP_205483829.1
• Coordinates: 4341042..4341446 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN403_RS19130	4336825..4338114	-	1290	WP_205487520.1	RbtT/DalT/CsbX family MFS transporter	-
JN403_RS19135	4338667..4339535	-	869	Protein_3770	NmrA family NAD(P)-binding protein	-
JN403_RS19140	4339720..4340613	+	894	WP_205483827.1	LysR family transcriptional regulator	-
JN403_RS19145	4340824..4341003	+	180	WP_122534666.1	type II toxin-antitoxin system HicA family toxin	Toxin
JN403_RS19150	4341042..4341446	+	405	WP_205483829.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JN403_RS19155	4341538..4342410	-	873	WP_205483831.1	protein kinase	-
JN403_RS19160	4342556..4343284	-	729	WP_205483833.1	protein phosphatase 2C domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6623.77 Da
• Isoelectric Point: 10.4708

>T188826 WP_122534666.1 NZ_CP068986:4340824-4341003 [Pseudomonas sp. 15A4]
VKSRELISELEAAGWSLARIRGSHHIYTHPCSCHSIPVPHPKKDLPIGTIKSIRRRACL

Nucleotide

• Length: 180 bp

>T188826 NZ_CP090570:c4292475-4292302 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14725.64 Da
• Isoelectric Point: 4.4807

>AT188826 WP_205483829.1 NZ_CP068986:4341042-4341446 [Pseudomonas sp. 15A4]
MQYPIAIEWGDDTTAIGIQIPDIPGAVTAGDTFEEAYNAAVEIAHICLEELVSDGHPVPMPSSARAYHGHDDFVNMGWGM
VEIDITPYLGKTEKVNVTLPGFVIQRIDRYVRDHNVKSRSSFLADAALEKLGRV

Nucleotide

• Length: 405 bp

>AT188826 NZ_CP090570:c4292799-4292503 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG