Detailed information of TA system TA188825

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 4111434..4111981
• Replicon: chromosome
• Accession: NZ_CP068986
• Organism: Pseudomonas sp. 15A4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JN403_RS18095
• Protein ID: WP_122537187.1
• Coordinates: 4111434..4111709 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JN403_RS18100
• Protein ID: WP_122537276.1
• Coordinates: 4111709..4111981 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN403_RS18075	4107072..4108709	+	1638	WP_205483582.1	MCP four helix bundle domain-containing protein	-
JN403_RS18080	4108930..4109316	+	387	WP_205483583.1	copper homeostasis periplasmic binding protein CopC	-
JN403_RS18085	4109321..4110183	+	863	Protein_3563	copper homeostasis membrane protein CopD	-
JN403_RS18090	4110280..4111377	+	1098	WP_205483585.1	bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada	-
JN403_RS18095	4111434..4111709	-	276	WP_122537187.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JN403_RS18100	4111709..4111981	-	273	WP_122537276.1	ribbon-helix-helix domain-containing protein	Antitoxin
JN403_RS18105	4112209..4112664	+	456	WP_122537188.1	DUF2384 domain-containing protein	-
JN403_RS18110	4112664..4113107	+	444	WP_205483586.1	RES domain-containing protein	-
JN403_RS18115	4113108..4114091	-	984	WP_205483588.1	acryloyl-CoA reductase	-
JN403_RS18120	4114141..4114779	-	639	WP_172612077.1	TetR family transcriptional regulator C-terminal domain-containing protein	-
JN403_RS18125	4114872..4115947	+	1076	Protein_3571	nitronate monooxygenase	-
JN403_RS18130	4116087..4116854	+	768	WP_205483590.1	molybdate ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (10-47)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10685.23 Da
• Isoelectric Point: 8.5042

>T188825 WP_122537187.1 NZ_CP068986:c4111709-4111434 [Pseudomonas sp. 15A4]
MELKWTSKALSDIARLYEFLAAANQPAAARTVQQLTAAPTTLLVNPRIGERLEEFEPRDVRRIQIGHYEMRYEIANSTIY
LLRLWHTREDR

Nucleotide

• Length: 276 bp

>T188825 NZ_CP090570:4279886-4280263 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10045.30 Da
• Isoelectric Point: 5.6088

>AT188825 WP_122537276.1 NZ_CP068986:c4111981-4111709 [Pseudomonas sp. 15A4]
MATSAKTRSVTAHVPEALAQKVDLMAERLERSKNWIVKQALSAWIDQEEERSRLTREALADVDAGHVIDHQTVQAWADSL
STDTPLPVPR

Nucleotide

• Length: 273 bp

>AT188825 NZ_CP090570:4279465-4279839 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA