Detailed information of TA system TA188824

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 849923..850493
• Replicon: chromosome
• Accession: NZ_CP068986
• Organism: Pseudomonas sp. 15A4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JN403_RS03780
• Protein ID: WP_122534372.1
• Coordinates: 850209..850493 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JN403_RS03775
• Protein ID: WP_122534143.1
• Coordinates: 849923..850222 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN403_RS03760	845494..847511	-	2018	Protein_733	hypothetical protein	-
JN403_RS03765	847518..848627	-	1110	WP_205485429.1	tyrosine-type recombinase/integrase	-
JN403_RS03770	848726..849862	+	1137	Protein_735	YifB family Mg chelatase-like AAA ATPase	-
JN403_RS03775	849923..850222	+	300	WP_122534143.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JN403_RS03780	850209..850493	+	285	WP_122534372.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JN403_RS03785	850544..852520	-	1977	WP_205485431.1	Cache 3/Cache 2 fusion domain-containing protein	-
JN403_RS03790	852739..853659	-	921	WP_108121193.1	LysR family transcriptional regulator	-
JN403_RS03795	853823..855205	+	1383	WP_172610281.1	NorM family multidrug efflux MATE transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	817357..860238	42881

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-52)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10765.50 Da
• Isoelectric Point: 8.4717

>T188824 WP_122534372.1 NZ_CP068986:850209-850493 [Pseudomonas sp. 15A4]
VLTIEWSRYAKDDLLAILEYIAGHDAKAAWRLKEEIDVRIDHLPRHPRLYKAGREAGTREIVVAPNYLVVYAETPTALLI
LRVLHAAQQWPPKA

Nucleotide

• Length: 285 bp

>T188824 NZ_CP090570:3731233-3731511 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGCTCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10785.15 Da
• Isoelectric Point: 6.4821

>AT188824 WP_122534143.1 NZ_CP068986:849923-850222 [Pseudomonas sp. 15A4]
VTTQTSMLHVRIDQALKNQASETLASFGLTISDAVRILLTRVVREGGLPAGLGAHPDAYDKWFRAKVREAMDDSGPTHSH
EDVMAAATELLERKRGADN

Nucleotide

• Length: 300 bp

>AT188824 NZ_CP090570:3730970-3731230 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGACCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA