Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 3759896..3760566 Replicon chromosome
Accession NZ_CP068985
Organism Nonomuraea coxensis DSM 45129

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag Nocox_RS17585 Protein ID WP_020540103.1
Coordinates 3760147..3760566 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag Nocox_RS17580 Protein ID WP_020540104.1
Coordinates 3759896..3760147 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Nocox_RS17560 (Nocox_17520) 3755458..3756687 + 1230 WP_020540108.1 cytochrome P450 -
Nocox_RS17565 (Nocox_17525) 3756695..3758098 - 1404 WP_020540107.1 MFS transporter -
Nocox_RS17570 (Nocox_17530) 3758095..3758772 - 678 WP_020540106.1 TetR/AcrR family transcriptional regulator -
Nocox_RS17575 (Nocox_17535) 3759044..3759688 - 645 WP_020540105.1 biliverdin-producing heme oxygenase -
Nocox_RS17580 (Nocox_17540) 3759896..3760147 + 252 WP_020540104.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Nocox_RS17585 (Nocox_17545) 3760147..3760566 + 420 WP_020540103.1 type II toxin-antitoxin system VapC family toxin Toxin
Nocox_RS17590 (Nocox_17550) 3760570..3761934 - 1365 WP_020540102.1 hypothetical protein -
Nocox_RS17595 (Nocox_17555) 3762019..3762648 - 630 WP_246649872.1 response regulator transcription factor -
Nocox_RS17600 (Nocox_17560) 3762767..3764050 - 1284 WP_020540100.1 sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-62)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15336.56 Da        Isoelectric Point: 9.0107

>T188823 WP_020540103.1 NZ_CP068985:3760147-3760566 [Nonomuraea coxensis DSM 45129]
MVGYLLDTNVVSEVRKRNGSPYVRDWIGGAHGPTLYLSALTVGEIRCGVELRRPKDPAQATLLERWLHNLHRQFGDRIVP
VTPEVAEEWGRMNAVRPLPTTDGLIAATARVHGWTLVSRNVKDFAGTGVSVVNPFEPLG

Download         Length: 420 bp

>T188823 NZ_CP090570:3519380-3519598 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9811.89 Da        Isoelectric Point: 4.3865

>AT188823 WP_020540104.1 NZ_CP068985:3759896-3760147 [Nonomuraea coxensis DSM 45129]
MSGWQVQEAKQRFSEVVRRAVSEGPQVVTRHGEEVAVVIDIAEYRRLRGETPDFRKFLLEEPDWDDDLDLPRNRDLPREV
DFD

Download         Length: 252 bp

>AT188823 NZ_CP090570:3518980-3519354 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References