Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-Phd |
| Location | 3759896..3760566 | Replicon | chromosome |
| Accession | NZ_CP068985 | ||
| Organism | Nonomuraea coxensis DSM 45129 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | Nocox_RS17585 | Protein ID | WP_020540103.1 |
| Coordinates | 3760147..3760566 (+) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | Nocox_RS17580 | Protein ID | WP_020540104.1 |
| Coordinates | 3759896..3760147 (+) | Length | 84 a.a. |
Genomic Context
Location: 3755458..3756687 (1230 bp)
Type: Others
Protein ID: WP_020540108.1
Type: Others
Protein ID: WP_020540108.1
Location: 3759896..3760147 (252 bp)
Type: Antitoxin
Protein ID: WP_020540104.1
Type: Antitoxin
Protein ID: WP_020540104.1
Location: 3760147..3760566 (420 bp)
Type: Toxin
Protein ID: WP_020540103.1
Type: Toxin
Protein ID: WP_020540103.1
Location: 3756695..3758098 (1404 bp)
Type: Others
Protein ID: WP_020540107.1
Type: Others
Protein ID: WP_020540107.1
Location: 3758095..3758772 (678 bp)
Type: Others
Protein ID: WP_020540106.1
Type: Others
Protein ID: WP_020540106.1
Location: 3759044..3759688 (645 bp)
Type: Others
Protein ID: WP_020540105.1
Type: Others
Protein ID: WP_020540105.1
Location: 3760570..3761934 (1365 bp)
Type: Others
Protein ID: WP_020540102.1
Type: Others
Protein ID: WP_020540102.1
Location: 3762019..3762648 (630 bp)
Type: Others
Protein ID: WP_246649872.1
Type: Others
Protein ID: WP_246649872.1
Location: 3762767..3764050 (1284 bp)
Type: Others
Protein ID: WP_020540100.1
Type: Others
Protein ID: WP_020540100.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| Nocox_RS17560 (Nocox_17520) | 3755458..3756687 | + | 1230 | WP_020540108.1 | cytochrome P450 | - |
| Nocox_RS17565 (Nocox_17525) | 3756695..3758098 | - | 1404 | WP_020540107.1 | MFS transporter | - |
| Nocox_RS17570 (Nocox_17530) | 3758095..3758772 | - | 678 | WP_020540106.1 | TetR/AcrR family transcriptional regulator | - |
| Nocox_RS17575 (Nocox_17535) | 3759044..3759688 | - | 645 | WP_020540105.1 | biliverdin-producing heme oxygenase | - |
| Nocox_RS17580 (Nocox_17540) | 3759896..3760147 | + | 252 | WP_020540104.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| Nocox_RS17585 (Nocox_17545) | 3760147..3760566 | + | 420 | WP_020540103.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| Nocox_RS17590 (Nocox_17550) | 3760570..3761934 | - | 1365 | WP_020540102.1 | hypothetical protein | - |
| Nocox_RS17595 (Nocox_17555) | 3762019..3762648 | - | 630 | WP_246649872.1 | response regulator transcription factor | - |
| Nocox_RS17600 (Nocox_17560) | 3762767..3764050 | - | 1284 | WP_020540100.1 | sensor histidine kinase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15336.56 Da Isoelectric Point: 9.0107
>T188823 WP_020540103.1 NZ_CP068985:3760147-3760566 [Nonomuraea coxensis DSM 45129]
MVGYLLDTNVVSEVRKRNGSPYVRDWIGGAHGPTLYLSALTVGEIRCGVELRRPKDPAQATLLERWLHNLHRQFGDRIVP
VTPEVAEEWGRMNAVRPLPTTDGLIAATARVHGWTLVSRNVKDFAGTGVSVVNPFEPLG
MVGYLLDTNVVSEVRKRNGSPYVRDWIGGAHGPTLYLSALTVGEIRCGVELRRPKDPAQATLLERWLHNLHRQFGDRIVP
VTPEVAEEWGRMNAVRPLPTTDGLIAATARVHGWTLVSRNVKDFAGTGVSVVNPFEPLG
Download Length: 420 bp
>T188823 NZ_CP090570:3519380-3519598 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9811.89 Da Isoelectric Point: 4.3865
>AT188823 WP_020540104.1 NZ_CP068985:3759896-3760147 [Nonomuraea coxensis DSM 45129]
MSGWQVQEAKQRFSEVVRRAVSEGPQVVTRHGEEVAVVIDIAEYRRLRGETPDFRKFLLEEPDWDDDLDLPRNRDLPREV
DFD
MSGWQVQEAKQRFSEVVRRAVSEGPQVVTRHGEEVAVVIDIAEYRRLRGETPDFRKFLLEEPDWDDDLDLPRNRDLPREV
DFD
Download Length: 252 bp
>AT188823 NZ_CP090570:3518980-3519354 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG