Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 3402376..3402983 Replicon chromosome
Accession NZ_CP068983
Organism Paradevosia shaoguanensis strain J5-3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JNE37_RS16445 Protein ID WP_203063872.1
Coordinates 3402376..3402558 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JNE37_RS16450 Protein ID WP_203063874.1
Coordinates 3402564..3402983 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNE37_RS16425 3397421..3397687 + 267 WP_035028977.1 flagellar biosynthetic protein FliQ -
JNE37_RS16430 3397691..3398458 + 768 WP_203063867.1 flagellar type III secretion system protein FliR -
JNE37_RS16435 3398499..3399593 + 1095 WP_203063869.1 flagellar biosynthesis protein FlhB -
JNE37_RS16440 3399667..3402213 + 2547 WP_203063870.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
JNE37_RS16445 3402376..3402558 + 183 WP_203063872.1 type II toxin-antitoxin system HicA family toxin Toxin
JNE37_RS16450 3402564..3402983 + 420 WP_203063874.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JNE37_RS16455 3402980..3404008 - 1029 WP_203063876.1 aldo/keto reductase -
JNE37_RS16460 3404093..3405088 - 996 WP_203063878.1 GguC protein -
JNE37_RS16465 3405423..3406496 + 1074 WP_035028994.1 recombinase RecA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

Cro/C1-type helix-turn-helix domain

(79-132)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6591.68 Da        Isoelectric Point: 11.6050

>T188820 WP_203063872.1 NZ_CP068983:3402376-3402558 [Paradevosia shaoguanensis]
MTSAQFRRWLAKQGCTFEPGNGGHLLVRRGNTRSVLPMHGSGKELGTGLVRKIKKDLGLE

Download         Length: 183 bp

>T188820 NZ_CP090570:2449819-2451141 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGTGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15128.30 Da        Isoelectric Point: 5.2389

>AT188820 WP_203063874.1 NZ_CP068983:3402564-3402983 [Paradevosia shaoguanensis]
MRYAVELTPDDNGTLLATVPDLPEVATFGENEEVALGHAIDAIATAIQGRMSDRETVPEPGPVGQHSVTLPALSVMKVAL
YRAMLAAGLRKSDLGRRLGWKPAQVDRLFNLRHASRVDQIEEAFRVLGKSLEIEVRDAA

Download         Length: 420 bp

>AT188820 NZ_CP090570:2449553-2449819 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References