Detailed information of TA system TA188819

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 2487776..2488281
• Replicon: chromosome
• Accession: NZ_CP068983
• Organism: Paradevosia shaoguanensis strain J5-3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JNE37_RS11900
• Protein ID: WP_203062943.1
• Coordinates: 2487776..2488030 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JNE37_RS11905
• Protein ID: WP_203062944.1
• Coordinates: 2488027..2488281 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNE37_RS11885	2484881..2485879	+	999	WP_182399355.1	ligase-associated DNA damage response exonuclease	-
JNE37_RS11890	2485876..2487453	+	1578	WP_203062941.1	cisplatin damage response ATP-dependent DNA ligase	-
JNE37_RS11895	2487462..2487767	+	306	WP_203062942.1	UvrB/UvrC motif-containing protein	-
JNE37_RS11900	2487776..2488030	-	255	WP_203062943.1	Txe/YoeB family addiction module toxin	Toxin
JNE37_RS11905	2488027..2488281	-	255	WP_203062944.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
JNE37_RS11910	2488313..2488702	-	390	WP_035035585.1	MerR family DNA-binding protein	-
JNE37_RS11915	2488689..2490410	-	1722	WP_203062945.1	long-chain fatty acid--CoA ligase	-
JNE37_RS11920	2490618..2493068	+	2451	WP_203062946.1	acyl-CoA dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10053.41 Da
• Isoelectric Point: 8.4762

>T188819 WP_203062943.1 NZ_CP068983:c2488030-2487776 [Paradevosia shaoguanensis]
VKLTFSDDGWEDYLHWQAQDKKLLKRLNALIKECQRTPFSGTGKPEPLKGELSGYWSRRLDQEHRLVYRYAEDALEIVQC
RKHY

Nucleotide

• Length: 255 bp

>T188819 NZ_CP090570:2110640-2110743 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9495.88 Da
• Isoelectric Point: 8.6184

>AT188819 WP_203062944.1 NZ_CP068983:c2488281-2488027 [Paradevosia shaoguanensis]
MRTKSISDFRKNIAEDINDVVEDHVPLLITRGGGKPAAVVMSLEDFASWQETNYLLGSPKNAKRLLRSIRQLEEGKATER
KLIE

Nucleotide

• Length: 255 bp

>AT188819 NZ_CP090570:c2110781-2110510 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT