Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 1957033..1957648 Replicon chromosome
Accession NZ_CP068983
Organism Paradevosia shaoguanensis strain J5-3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JNE37_RS09260 Protein ID WP_203066041.1
Coordinates 1957033..1957428 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JNE37_RS09265 Protein ID WP_203066042.1
Coordinates 1957418..1957648 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNE37_RS09225 1952074..1952808 - 735 WP_203066036.1 uroporphyrinogen-III synthase -
JNE37_RS09230 1952805..1953752 - 948 WP_203066037.1 hydroxymethylbilane synthase -
JNE37_RS09235 1953785..1954885 + 1101 WP_203066038.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD -
JNE37_RS09240 1954875..1955843 + 969 WP_203066039.1 NAD(P)-dependent glycerol-3-phosphate dehydrogenase -
JNE37_RS09245 1955847..1956140 + 294 WP_203066040.1 YciI family protein -
JNE37_RS09250 1956142..1956561 + 420 WP_035037291.1 EVE domain-containing protein -
JNE37_RS09255 1956632..1957036 + 405 WP_182399030.1 DUF1761 domain-containing protein -
JNE37_RS09260 1957033..1957428 - 396 WP_203066041.1 PIN domain-containing protein Toxin
JNE37_RS09265 1957418..1957648 - 231 WP_203066042.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JNE37_RS09270 1957709..1957909 - 201 WP_203066043.1 DUF1674 domain-containing protein -
JNE37_RS09275 1958021..1959010 + 990 WP_203066360.1 zinc metalloprotease HtpX -
JNE37_RS09280 1959017..1960324 + 1308 WP_203066044.1 RsmB/NOP family class I SAM-dependent RNA methyltransferase -
JNE37_RS09285 1960403..1962049 + 1647 WP_203066045.1 heparinase II/III family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-117)

Antitoxin

SpoVT-AbrB domain

(5-43)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14154.33 Da        Isoelectric Point: 4.6652

>T188816 WP_203066041.1 NZ_CP068983:c1957428-1957033 [Paradevosia shaoguanensis]
MSGSFIDTNILLYALSADRQKADRAEAVLSAGGIVSVQVLNEFAAVARRKLGLPYPEIAYLLATYRGLVEVRPLTVEIHL
AGLALAGEHDLSIYDAMIVASALEAGCDVLYSEDMQAGRVFEGRLRLVNPF

Download         Length: 396 bp

>T188816 NZ_CP090570:765921-766217 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8732.00 Da        Isoelectric Point: 5.8607

>AT188816 WP_203066042.1 NZ_CP068983:c1957648-1957418 [Paradevosia shaoguanensis]
MLVSKWGNSLAVRLPASVVDALDLKEGDEVTLRIEDERDFVVERKPGRAQLLERLRKHRGILPADFVFDRDCANER

Download         Length: 231 bp

>AT188816 NZ_CP090570:766219-766614 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References