Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5142830..5143455 Replicon chromosome
Accession NZ_CP068972
Organism Klebsiella pneumoniae strain fekpn2511

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JN237_RS24935 Protein ID WP_062921072.1
Coordinates 5142830..5143213 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JN237_RS24940 Protein ID WP_004150355.1
Coordinates 5143213..5143455 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN237_RS24920 5140196..5141098 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
JN237_RS24925 5141095..5141730 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JN237_RS24930 5141727..5142656 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
JN237_RS24935 5142830..5143213 - 384 WP_062921072.1 type II toxin-antitoxin system VapC family toxin Toxin
JN237_RS24940 5143213..5143455 - 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
JN237_RS24945 5143660..5144577 + 918 WP_065888547.1 alpha/beta hydrolase -
JN237_RS24950 5144591..5145532 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JN237_RS24955 5145577..5146014 - 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
JN237_RS24960 5146011..5146871 - 861 WP_004146232.1 virulence factor BrkB family protein -
JN237_RS24965 5146865..5147464 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T188804 WP_062921072.1 NZ_CP068972:c5143213-5142830 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDALILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T188804 NZ_CP090568:487512-487664 [Xanthomonas citri pv. malvacearum]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGACGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCTGAAAAATGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT188804 WP_004150355.1 NZ_CP068972:c5143455-5143213 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT188804 NZ_CP090568:487739-487873 [Xanthomonas citri pv. malvacearum]
ATGAAGCGTGCAATTGTGCTGCTGGTGTTATCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References