Detailed information of TA system TA188803

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4663826..4664342
• Replicon: chromosome
• Accession: NZ_CP068972
• Organism: Klebsiella pneumoniae strain fekpn2511

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JN237_RS22660
• Protein ID: WP_040216106.1
• Coordinates: 4663826..4664110 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: JN237_RS22665
• Protein ID: WP_002886901.1
• Coordinates: 4664100..4664342 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN237_RS22635	4659243..4659551	-	309	WP_012737232.1	PTS sugar transporter subunit IIB	-
JN237_RS22640	4659636..4659809	+	174	WP_032425422.1	hypothetical protein	-
JN237_RS22645	4659812..4660555	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
JN237_RS22650	4660912..4663050	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
JN237_RS22655	4663358..4663822	+	465	WP_032418146.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
JN237_RS22660	4663826..4664110	-	285	WP_040216106.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JN237_RS22665	4664100..4664342	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JN237_RS22670	4664420..4666330	-	1911	WP_040216105.1	BglG family transcription antiterminator	-
JN237_RS22675	4666353..4667507	-	1155	WP_040216103.1	lactonase family protein	-
JN237_RS22680	4667574..4668314	-	741	WP_004186692.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11097.94 Da
• Isoelectric Point: 10.4962

>T188803 WP_040216106.1 NZ_CP068972:c4664110-4663826 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T188803 NZ_CP090568:c227214-226933 [Xanthomonas citri pv. malvacearum]
ATGCGGACGATTGACCGTTCATCCGCTTTCAAGCGCGACTACAAGCGGGAAGCCAAGGGGCAGCATCGCGCCACGCTTGA
TGACGCGATCAAGCCGGTGTTGGTCGCACTGGCGACCGATCAGCCTCCCGATGCACGCTATCGCGATCACGATCTTTCCG
GCGATTGGGCGGGCTATCGGGAATGTCACATCAAGCCCGACTTGCTGCTGATCTACCGCAAGTCCGACCCCGACACCCTG
CGACTGGCACGGCTTGGCTCGCACAGCGAGCTTTTCGGCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT188803 WP_002886901.1 NZ_CP068972:c4664342-4664100 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT188803 NZ_CP090568:c227470-227201 [Xanthomonas citri pv. malvacearum]
ATGAGCACTACCGCCGATACCTACGTCCGCGCCCGCATCGACACCGCCACCAAGGAACGTGCCGCTAGTGCGCTCGAAGC
AATGGGGCTGTCGATCTCTGATGCTATCCGCCTGCTGATGCTACGCATTGCCGACGAACACCGCCTGCCCTTCGATGTGA
AGGTACCAAACACCACCACGAAAAAGGCGATTGCCGAACTGGAATCAGGCAAGGGTAAGAAGTTCGCCAATGTGGACGAC
CTGATGGCGGATTTGCATGCGGACGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0