Detailed information of TA system TA188789

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 794150..794807
• Replicon: chromosome
• Accession: NZ_CP068972
• Organism: Klebsiella pneumoniae strain fekpn2511

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: JN237_RS03945
• Protein ID: WP_040245400.1
• Coordinates: 794397..794807 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: JN237_RS03940
• Protein ID: WP_002916312.1
• Coordinates: 794150..794416 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN237_RS03915	789306..790739	-	1434	WP_203144529.1	6-phospho-beta-glucosidase	-
JN237_RS03920	790858..791586	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
JN237_RS03925	791636..791947	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
JN237_RS03930	792111..792770	+	660	WP_048334397.1	hemolysin III family protein	-
JN237_RS03935	792921..793904	-	984	WP_032430613.1	tRNA-modifying protein YgfZ	-
JN237_RS03940	794150..794416	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
JN237_RS03945	794397..794807	+	411	WP_040245400.1	protein YgfX	Toxin
JN237_RS03950	794814..795335	-	522	WP_002916308.1	flavodoxin FldB	-
JN237_RS03955	795436..796332	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
JN237_RS03960	796355..797068	+	714	WP_048290928.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
JN237_RS03965	797074..798807	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16035.83 Da
• Isoelectric Point: 11.4778

>T188789 WP_040245400.1 NZ_CP068972:794397-794807 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDSRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T188789 NZ_CP090561:c2763277-2762888 [Xanthomonas citri pv. malvacearum]
ATGCTTGATACCAACACCGTGAGCCATCTCGTCAAAAGCCATCCGGCTGTCTCTCGACGGGTCATTGAAGTGCCTATGAC
TGCGCTATGTATGTCCGCAATTACCGGTGGGGAGCTGATGTTCGGCTTGGCTAAGGTGCCAGACGCCAAACGCCTTCAGC
AAGCCGTCATGGAACTCCTGCGGCGCGTGGATGTGCTGCCTTGGGATGGCGCGGTAATGGAGCGTTACGGAAGCGTAAGA
GCGGACCTAGAAAAGCAAGGTAAAGCGCTTGGGTCGCTCGACATGCTTATCGCAGCACATGCACTGGAAACGGATTCTGT
CCTCGTTACCAATGACGCCGCATTTAGTCGTGTTGTTGGTTTGACCGTGGAAGATTGGACACGCAGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT188789 WP_002916312.1 NZ_CP068972:794150-794416 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT188789 NZ_CP090561:c2763546-2763286 [Xanthomonas citri pv. malvacearum]
GTGAGCCAAGTTGCCAAGCTGTTCATCAATGGCCGCAGCCAGGCAGTCCGCTTGCCTGCCGCCTATCGCTTTACCGAGAA
AGAGGTTTTCATTCGCCAAGACCCGGAGACCGGTGACGTCATCCTGTCTCGGAAGCCTGCAACGTGGGAGGACTTCTTTA
TCGCACTCAAGAGCGCAGATGTGCCTGCTAATTTTCTAGATGCCGCCGAGCGCAATCAGGGCACGCAGGACCGTGATCCT
TTTGCGGGATGGCGCGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41