Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4605555..4606150 Replicon chromosome
Accession NZ_CP068830
Organism Escherichia coli strain RIVM_C018707

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag JNN82_RS22225 Protein ID WP_019842229.1
Coordinates 4605555..4605905 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag JNN82_RS22230 Protein ID WP_001223213.1
Coordinates 4605899..4606150 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN82_RS22205 4600885..4601907 - 1023 WP_001550507.1 ABC transporter permease -
JNN82_RS22210 4601921..4603423 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
JNN82_RS22215 4603555..4604511 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
JNN82_RS22220 4604821..4605351 + 531 WP_000055075.1 inorganic diphosphatase -
JNN82_RS22225 4605555..4605905 - 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
JNN82_RS22230 4605899..4606150 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
JNN82_RS22235 4606362..4606703 - 342 WP_001550504.1 gamma-glutamylcyclotransferase -
JNN82_RS22240 4606706..4610485 - 3780 WP_001550503.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T188784 WP_019842229.1 NZ_CP068830:c4605905-4605555 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T188784 NZ_CP090561:214112-214438 [Xanthomonas citri pv. malvacearum]
ATGATGCGGGGTGACTTTGTGACCATCGCCATGCAAGGCGACTTCGGAAAACCACGGCCCGCTCTGGTGATCCAGGCCGA
CCAGTTTGACGCACACACCACCGTGACGGTGCTGCCGGTGACAAGCACGCTCGTTGCTGCGCCGCTGCTGCGCATTACCA
TTCATCCAAGTACCGACAATGGTTTGCAGAAGCCGTCTCAGGTGATGGTGGACAAGGCCATGACCGTGAAGCGTGACAAG
GTAGGTCGAGCCTTTGGGCGCGTAGACGCTGATGCGTTGGTGGAAATTGAGCGCTGCCTGGCCGTGTTCTTGGGCATCGC
TAAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT188784 WP_001223213.1 NZ_CP068830:c4606150-4605899 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT188784 NZ_CP090561:213945-214115 [Xanthomonas citri pv. malvacearum]
ATGGCAGGGCTGCGTCCGGTGCAAATTTGGGTGCCGGACACACGGCGGCCTGACTTCGCCGAGGAATGCCGCCGTCAGTG
TCGTCTTGCTGCACAAGCGGACATGGCGGACACCGACATGCAGCGCTTCATGGATGAGGCGCTAGCAGACATGGATGGCT
GGACGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References