Detailed information of TA system TA188782

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4486736..4487556
• Replicon: chromosome
• Accession: NZ_CP068830
• Organism: Escherichia coli strain RIVM_C018707

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A0V9MKL8
• Locus tag: JNN82_RS21635
• Protein ID: WP_001550554.1
• Coordinates: 4486736..4486993 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: JNN82_RS21640
• Protein ID: WP_001519303.1
• Coordinates: 4487005..4487556 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN82_RS21615	4482022..4483128	+	1107	WP_001519308.1	N-acetylneuraminate epimerase	-
JNN82_RS21620	4483193..4484173	+	981	WP_001519307.1	transposase	-
JNN82_RS21625	4484756..4485997	-	1242	Protein_4233	helicase YjhR	-
JNN82_RS21630	4486060..4486359	+	300	WP_001519304.1	GNAT family N-acetyltransferase	-
JNN82_RS21635	4486736..4486993	+	258	WP_001550554.1	hypothetical protein	Toxin
JNN82_RS21640	4487005..4487556	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
JNN82_RS21645	4487608..4487769	+	162	WP_001519302.1	hypothetical protein	-
JNN82_RS21650	4487806..4488354	+	549	WP_001519301.1	hypothetical protein	-
JNN82_RS21655	4488481..4488741	+	261	WP_000084876.1	hypothetical protein	-
JNN82_RS21660	4488779..4488895	+	117	Protein_4240	VOC family protein	-
JNN82_RS21665	4489140..4490261	+	1122	WP_000010833.1	M42 family metallopeptidase	-
JNN82_RS21670	4490258..4490536	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
JNN82_RS21675	4490548..4491861	+	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	4479220..4487769	8549

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9744.33 Da
• Isoelectric Point: 11.0090

>T188782 WP_001550554.1 NZ_CP068830:4486736-4486993 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T188782 NZ_CP090559:23256-23597 [Enterococcus faecalis]
ATGAGTGACGAAAAGAAATATATTCCTAAAAAGGGCGATATTGTATGGATAGATTTCGATCCTTCAGCTGAAAAAGAAAT
ACAGAAAAGACGTCCAGGTCTAGTAGTTTCTAGATATGAGTTTAATAGAAAGACATTGTTTGCAGTAATTTGTCCCATAA
CTTCTACAATTAAAAATATGCCAACTCGTTATACATTACCTGATGAAATGGAAACTCATGGACAAGTCGTTATTTCCCAA
TTAAAATCTTTAGACTTTGCAGAAAGAAAGTTAAGCCAAATAGAATATTTACCATTAAAGGATATGGCTAAAATAGATCA
AATCATTGAATACATTTTTTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT188782 WP_001519303.1 NZ_CP068830:4487005-4487556 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT188782 NZ_CP090559:23026-23256 [Enterococcus faecalis]
ATGTTAACCACAAAATCTAGAAAACAAGGAAGTTCTGTAGTATTGACATTACCATCTAATAACGGACAGAAACCAAAAGC
AGACCAAGAATATATAGTAATGTATTCTGATGATGGGACAATTACGTTAGTCCCTATATTACAAGACCCATTTAGTGGTG
GATCAGAAGGGGAGTACTACGAAAAAGATGAATGGCATGACATTGAACCTGGAGGGAGAGAATTATTTTAA

Structures

Toxin

• AlphaFold DB: A0A0V9MKL8