Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3862066..3862684 Replicon chromosome
Accession NZ_CP068830
Organism Escherichia coli strain RIVM_C018707

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JNN82_RS18615 Protein ID WP_001291435.1
Coordinates 3862466..3862684 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag JNN82_RS18610 Protein ID WP_000344800.1
Coordinates 3862066..3862440 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN82_RS18600 3857155..3858348 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JNN82_RS18605 3858371..3861520 + 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
JNN82_RS18610 3862066..3862440 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
JNN82_RS18615 3862466..3862684 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
JNN82_RS18620 3862856..3863407 + 552 WP_060579167.1 maltose O-acetyltransferase -
JNN82_RS18625 3863523..3863993 + 471 WP_000136192.1 YlaC family protein -
JNN82_RS18630 3864157..3865707 + 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JNN82_RS18635 3865749..3866102 - 354 WP_001550741.1 DUF1428 family protein -
JNN82_RS18645 3866481..3866792 + 312 WP_000409911.1 MGMT family protein -
JNN82_RS18650 3866823..3867395 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T188778 WP_001291435.1 NZ_CP068830:3862466-3862684 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T188778 NZ_CP090558:521627-521743 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT188778 WP_000344800.1 NZ_CP068830:3862066-3862440 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT188778 NZ_CP090558:c521859-521654 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References