Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2074428..2075259 Replicon chromosome
Accession NZ_CP068830
Organism Escherichia coli strain RIVM_C018707

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag JNN82_RS09935 Protein ID WP_000854814.1
Coordinates 2074428..2074802 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag JNN82_RS09940 Protein ID WP_001285585.1
Coordinates 2074891..2075259 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN82_RS09895 2069824..2070990 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
JNN82_RS09900 2071109..2071582 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
JNN82_RS09905 2071780..2072838 + 1059 WP_001200891.1 FUSC family protein -
JNN82_RS09910 2073010..2073339 + 330 WP_000450409.1 DUF496 family protein -
JNN82_RS09915 2073440..2073622 - 183 WP_001016348.1 hypothetical protein -
JNN82_RS09920 2073694..2073822 + 129 Protein_1943 transposase domain-containing protein -
JNN82_RS09925 2074111..2074224 - 114 WP_001161660.1 DUF957 domain-containing protein -
JNN82_RS09930 2074237..2074431 - 195 WP_000988600.1 hypothetical protein -
JNN82_RS09935 2074428..2074802 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
JNN82_RS09940 2074891..2075259 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
JNN82_RS09945 2075333..2075554 - 222 WP_000692323.1 DUF987 domain-containing protein -
JNN82_RS09950 2075617..2076093 - 477 WP_039267628.1 RadC family protein -
JNN82_RS09955 2076109..2076588 - 480 WP_000860087.1 antirestriction protein -
JNN82_RS09960 2076670..2077488 - 819 WP_060626401.1 DUF945 domain-containing protein -
JNN82_RS09965 2077588..2077821 - 234 WP_001119729.1 DUF905 family protein -
JNN82_RS09970 2077896..2078351 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T188765 WP_000854814.1 NZ_CP068830:c2074802-2074428 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T188765 NZ_CP090547:2261236-2261535 [Xylella fastidiosa subsp. sandyi]
ATGACCTACACGGTAAAACGACTTGAAGGGTTCTCTGACTGGCTAAAGGGCCTAAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCGGTGGGTGAAGGCGTGTTTGAAATGCGCG
AACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGTGGCGGCGACAAG
TCAACGCAGCAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTGGAGGATTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT188765 WP_001285585.1 NZ_CP068830:c2075259-2074891 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT188765 NZ_CP090547:2261539-2261847 [Xylella fastidiosa subsp. sandyi]
GTGACCATAACAAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAACAGCGAAGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTGGGTGACATTGCCCGTTCAC
GTGGTATGTCTCAGATTGCGAAGGATTCTGGCATCACGCGGGAAGCTCTATACAAGGCCCTTCGGCCTGGTAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTAGGTATACGTCTAGTAGCGCAACCAATGCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References