Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4530928..4531523 Replicon chromosome
Accession NZ_CP068829
Organism Escherichia coli strain RIVM_C030453

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag JNN50_RS21750 Protein ID WP_019842229.1
Coordinates 4530928..4531278 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag JNN50_RS21755 Protein ID WP_001223213.1
Coordinates 4531272..4531523 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN50_RS21730 4526258..4527280 - 1023 WP_001550507.1 ABC transporter permease -
JNN50_RS21735 4527294..4528796 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
JNN50_RS21740 4528928..4529884 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
JNN50_RS21745 4530194..4530724 + 531 WP_000055075.1 inorganic diphosphatase -
JNN50_RS21750 4530928..4531278 - 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
JNN50_RS21755 4531272..4531523 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
JNN50_RS21760 4531735..4532076 - 342 WP_001550504.1 gamma-glutamylcyclotransferase -
JNN50_RS21765 4532079..4535858 - 3780 WP_001550503.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T188755 WP_019842229.1 NZ_CP068829:c4531278-4530928 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T188755 NZ_CP090547:c1473977-1473696 [Xylella fastidiosa subsp. sandyi]
ATGATCAAAAGTTTCCGCCACAAAGGCATTCAACAATTTTTCCTTGTGGGATCAACCGCTGGTATCCAAACCAAACACGC
CGCCAAACTGCGTATCCAGCTCACCGCGTTGGAGAGTGCCAAGCGCCCCGAAGATATGAATGCTCCAGGCTGGAAACTGC
ACCCACTAAAAGGCGCTGACTTAAAAGGTCATTGGTCCATCTGGGTGAATGGCAACTATCGCCTCACGTTTGCTTTTGAA
GGCGAAGACGCAATCTTGGTCGACTATCAGGATTATCACTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT188755 WP_001223213.1 NZ_CP068829:c4531523-4531272 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT188755 NZ_CP090547:c1473685-1473410 [Xylella fastidiosa subsp. sandyi]
ATGAAACGTATGCACAATCCCGCACATCCAGGTGAAGTGTTGCGTGAGTATCTTGGTGAGCTCACTGTGACCAATGCGGC
TGCAAAGCTAGGCGTCAGCCGTGTGGCTTTGTCGCGTATTCTCAATGGTACCAATGGCATCTCTGCCGATATGGCCCTTC
GCCTGGAAGATGCGCTTGGCACCAGTGCAGAGATGTGGGCAGCCATGCAGTTCAAGTATGACCTGTGGGTTGCTAGTCAG
CAGCCACGCCCGAAGATCACGCGCCTTCATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References