Detailed information of TA system TA188753

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4412116..4412936
• Replicon: chromosome
• Accession: NZ_CP068829
• Organism: Escherichia coli strain RIVM_C030453

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A0V9MKL8
• Locus tag: JNN50_RS21150
• Protein ID: WP_001550554.1
• Coordinates: 4412116..4412373 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: JNN50_RS21155
• Protein ID: WP_001519303.1
• Coordinates: 4412385..4412936 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN50_RS21130	4407402..4408508	+	1107	WP_001519308.1	N-acetylneuraminate epimerase	-
JNN50_RS21135	4408573..4409553	+	981	WP_001519307.1	transposase	-
JNN50_RS21140	4410136..4411377	-	1242	Protein_4139	helicase YjhR	-
JNN50_RS21145	4411440..4411739	+	300	WP_001519304.1	GNAT family N-acetyltransferase	-
JNN50_RS21150	4412116..4412373	+	258	WP_001550554.1	hypothetical protein	Toxin
JNN50_RS21155	4412385..4412936	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
JNN50_RS21160	4412988..4413149	+	162	WP_001519302.1	hypothetical protein	-
JNN50_RS21165	4413186..4413734	+	549	WP_001519301.1	hypothetical protein	-
JNN50_RS21170	4413861..4414121	+	261	WP_000084876.1	hypothetical protein	-
JNN50_RS21175	4414159..4414275	+	117	Protein_4146	VOC family protein	-
JNN50_RS21180	4414520..4415641	+	1122	WP_000010833.1	M42 family metallopeptidase	-
JNN50_RS21185	4415638..4415916	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
JNN50_RS21190	4415928..4417241	+	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	4404600..4413149	8549

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9744.33 Da
• Isoelectric Point: 11.0090

>T188753 WP_001550554.1 NZ_CP068829:4412116-4412373 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T188753 NZ_CP090547:c1060460-1060155 [Xylella fastidiosa subsp. sandyi]
ATGAATAATGAGACTTTTAGTCGATACGACACCGCTGACTATCTCAAAACCGAAGAAGATATTGCGGCTTATATGGAAGC
CGTCATGGAAGAAGGTGGTAGGGATAATCCTGCTTTTATTGCACGGGCACTTGGTGCCGTCGCTCGTGCTCGTAATTTAA
GTCAGCTGGCTCGTGACGTTGGCATGTCCAGGCAAGGACTAGACAAGGCACTCTCTAACGACGGCAACCCAAGCTTCTCA
ACCATCTTAAAAGTGGCTAAAGCGCTTGGTTTACGGATGTCATTCACACCTTCCTCTATGAGTTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT188753 WP_001519303.1 NZ_CP068829:4412385-4412936 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT188753 NZ_CP090547:c1060760-1060464 [Xylella fastidiosa subsp. sandyi]
ATGGTCGAACTCATCAAAACCAGCACTTTTGATGCTTGGATAAACAGCTTACGTGACCGCAAAGCAGCCGCCAGAATTCA
AGCGCGTCTTGATCGGCTCGCACTTGGCAATCCCGGCGACGTGAAGCCTGTGGGTGCTGGCATATCAGAAATGAGGATCG
ACCATGGGCCCGGATATCGGATCTATTTTATGAAGCATGGTGCAGTACTGATTCTCTTACTTTGCGGTGGCGATAAATCG
TCACAAGTACGAGATATAGAGCAGGCTAAGGCACTGGCTGCACTGTGGAAGGATTAG

Structures

Toxin

• AlphaFold DB: A0A0V9MKL8