Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 830422..831257 Replicon chromosome
Accession NZ_CP068829
Organism Escherichia coli strain RIVM_C030453

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0A1A9A5
Locus tag JNN50_RS03925 Protein ID WP_001564063.1
Coordinates 830422..830799 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0K5N986
Locus tag JNN50_RS03930 Protein ID WP_021553056.1
Coordinates 830889..831257 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN50_RS03895 825993..826976 - 984 WP_001296394.1 KpsF/GutQ family sugar-phosphate isomerase -
JNN50_RS03900 827128..827825 + 698 Protein_765 IS1 family transposase -
JNN50_RS03905 828563..828733 - 171 Protein_766 IS110 family transposase -
JNN50_RS03910 829076..829918 - 843 Protein_767 DUF4942 domain-containing protein -
JNN50_RS03915 830003..830197 - 195 WP_024181941.1 DUF957 domain-containing protein -
JNN50_RS03920 830276..830425 - 150 Protein_769 hypothetical protein -
JNN50_RS03925 830422..830799 - 378 WP_001564063.1 TA system toxin CbtA family protein Toxin
JNN50_RS03930 830889..831257 - 369 WP_021553056.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN50_RS03935 831420..831641 - 222 WP_000692345.1 DUF987 domain-containing protein -
JNN50_RS03940 831706..832182 - 477 WP_021553055.1 RadC family protein -
JNN50_RS03945 832198..832677 - 480 WP_001564060.1 antirestriction protein -
JNN50_RS03950 832943..833761 - 819 WP_001564059.1 DUF945 domain-containing protein -
JNN50_RS03955 833851..834084 - 234 WP_001278293.1 DUF905 family protein -
JNN50_RS03960 834090..834767 - 678 WP_001564058.1 hypothetical protein -
JNN50_RS03965 834918..835598 - 681 WP_001278649.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - papX 828949..902530 73581
- flank IS/Tn - - 827448..827825 377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14094.09 Da        Isoelectric Point: 7.8045

>T188733 WP_001564063.1 NZ_CP068829:c830799-830422 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T188733 NZ_CP090541:4768199-4768510 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13615.39 Da        Isoelectric Point: 7.0264

>AT188733 WP_021553056.1 NZ_CP068829:c831257-830889 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT188733 NZ_CP090541:4768507-4768953 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1A9A5

Antitoxin

Source ID Structure
AlphaFold DB A0A0K5N986

References