Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/DUF4065(antitoxin) |
| Location | 4721201..4722189 | Replicon | chromosome |
| Accession | NZ_CP068828 | ||
| Organism | Escherichia coli strain RIVM_C030443 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | JNN35_RS22750 | Protein ID | WP_014640052.1 |
| Coordinates | 4721201..4721587 (-) | Length | 129 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | A0A0J5Z6D5 |
| Locus tag | JNN35_RS22755 | Protein ID | WP_000458584.1 |
| Coordinates | 4721617..4722189 (-) | Length | 191 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JNN35_RS22700 | 4716525..4716887 | + | 363 | WP_000135682.1 | hypothetical protein | - |
| JNN35_RS22705 | 4716953..4717777 | + | 825 | WP_097333126.1 | DUF2303 family protein | - |
| JNN35_RS22710 | 4717905..4718441 | + | 537 | WP_094284483.1 | 5'-deoxynucleotidase | - |
| JNN35_RS22715 | 4718432..4719310 | + | 879 | WP_053287588.1 | phosphoadenosine phosphosulfate reductase family protein | - |
| JNN35_RS22720 | 4719307..4719510 | + | 204 | WP_000156999.1 | hypothetical protein | - |
| JNN35_RS22725 | 4719503..4719742 | + | 240 | WP_000476212.1 | hypothetical protein | - |
| JNN35_RS22730 | 4719739..4720050 | + | 312 | WP_000073886.1 | hypothetical protein | - |
| JNN35_RS22735 | 4720050..4720622 | + | 573 | WP_063501529.1 | 3'-5' exoribonuclease | - |
| JNN35_RS22740 | 4720659..4720940 | + | 282 | WP_001093918.1 | pyocin activator PrtN family protein | - |
| JNN35_RS22745 | 4720988..4721161 | - | 174 | WP_000390072.1 | hypothetical protein | - |
| JNN35_RS22750 | 4721201..4721587 | - | 387 | WP_014640052.1 | hypothetical protein | Toxin |
| JNN35_RS22755 | 4721617..4722189 | - | 573 | WP_000458584.1 | SocA family protein | Antitoxin |
| JNN35_RS22760 | 4722425..4722547 | - | 123 | WP_001300034.1 | hypothetical protein | - |
| JNN35_RS22765 | 4722910..4723872 | - | 963 | WP_202852081.1 | DUF2713 family protein | - |
| JNN35_RS22770 | 4724190..4724705 | + | 516 | WP_000416263.1 | zinc uptake transcriptional repressor Zur | - |
| JNN35_RS22775 | 4724747..4724956 | - | 210 | WP_001030593.1 | CsbD family protein | - |
| JNN35_RS22780 | 4725072..4726397 | - | 1326 | WP_001301116.1 | MATE family efflux transporter DinF | - |
| JNN35_RS22785 | 4726470..4727078 | - | 609 | WP_000646078.1 | transcriptional repressor LexA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4674273..4727556 | 53283 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 129 a.a. Molecular weight: 14465.40 Da Isoelectric Point: 5.4833
>T188729 WP_014640052.1 NZ_CP068828:c4721587-4721201 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE
Download Length: 387 bp
>T188729 NZ_CP090541:c4142211-4141924 [Salmonella enterica]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA
Antitoxin
Download Length: 191 a.a. Molecular weight: 21973.21 Da Isoelectric Point: 6.0283
>AT188729 WP_000458584.1 NZ_CP068828:c4722189-4721617 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHNVSLRSDPREMDADEVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHNVSLRSDPREMDADEVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS
Download Length: 573 bp
>AT188729 NZ_CP090541:c4141937-4141635 [Salmonella enterica]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|