Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 882812..883647 Replicon chromosome
Accession NZ_CP068828
Organism Escherichia coli strain RIVM_C030443

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2I6T1R7
Locus tag JNN35_RS04280 Protein ID WP_016231184.1
Coordinates 882812..883189 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7Z1I923
Locus tag JNN35_RS04285 Protein ID WP_016231183.1
Coordinates 883279..883647 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN35_RS04250 877926..879074 - 1149 WP_000905926.1 capsule polysaccharide export inner-membrane protein KpsE -
JNN35_RS04255 879146..880129 - 984 WP_001298261.1 KpsF/GutQ family sugar-phosphate isomerase -
JNN35_RS04260 880940..881110 - 171 Protein_838 IS110 family transposase -
JNN35_RS04265 881452..882021 - 570 WP_016231187.1 DUF4942 domain-containing protein -
JNN35_RS04270 882118..882315 - 198 WP_016231186.1 DUF957 domain-containing protein -
JNN35_RS04275 882327..882815 - 489 WP_016231185.1 hypothetical protein -
JNN35_RS04280 882812..883189 - 378 WP_016231184.1 TA system toxin CbtA family protein Toxin
JNN35_RS04285 883279..883647 - 369 WP_016231183.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN35_RS04290 883697..884185 - 489 WP_021824123.1 hypothetical protein -
JNN35_RS04295 884198..884341 - 144 WP_001521299.1 hypothetical protein -
JNN35_RS04300 884360..884581 - 222 WP_016231182.1 DUF987 domain-containing protein -
JNN35_RS04305 884644..885120 - 477 WP_001186774.1 RadC family protein -
JNN35_RS04310 885136..885621 - 486 WP_000849596.1 antirestriction protein -
JNN35_RS04315 885676..886494 - 819 WP_023909039.1 DUF945 domain-containing protein -
JNN35_RS04320 886594..886827 - 234 WP_001119719.1 DUF905 family protein -
JNN35_RS04325 886913..887317 + 405 WP_016231180.1 IS66 family insertion sequence hypothetical protein -
JNN35_RS04330 887314..887661 + 348 WP_000612617.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14106.07 Da        Isoelectric Point: 8.2905

>T188708 WP_016231184.1 NZ_CP068828:c883189-882812 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T188708 NZ_CP090539:c1109144-1108617 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13613.43 Da        Isoelectric Point: 6.8413

>AT188708 WP_016231183.1 NZ_CP068828:c883647-883279 [Escherichia coli]
MSDTLPGTTLPDNNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ

Download         Length: 369 bp

>AT188708 NZ_CP090539:c1109431-1109141 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I6T1R7

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z1I923

References