Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 72340..73172 Replicon chromosome
Accession NZ_CP068828
Organism Escherichia coli strain RIVM_C030443

Toxin (Protein)


Gene name yeeV Uniprot ID E3PN67
Locus tag JNN35_RS00305 Protein ID WP_000854775.1
Coordinates 72340..72714 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A426P7N5
Locus tag JNN35_RS00310 Protein ID WP_001285645.1
Coordinates 72804..73172 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN35_RS00275 67701..68624 - 924 WP_000535948.1 carboxylate/amino acid/amine transporter -
JNN35_RS00280 68735..69919 - 1185 WP_001547040.1 sugar efflux transporter -
JNN35_RS00285 70349..70477 - 129 Protein_56 virulence RhuM family protein -
JNN35_RS00290 70716..71558 - 843 WP_001274548.1 DUF4942 domain-containing protein -
JNN35_RS00295 71643..71840 - 198 WP_000772035.1 DUF957 domain-containing protein -
JNN35_RS00300 71852..72343 - 492 WP_000976825.1 hypothetical protein -
JNN35_RS00305 72340..72714 - 375 WP_000854775.1 TA system toxin CbtA family protein Toxin
JNN35_RS00310 72804..73172 - 369 WP_001285645.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN35_RS00315 73335..73556 - 222 WP_000692303.1 DUF987 domain-containing protein -
JNN35_RS00320 73625..74101 - 477 WP_001186768.1 RadC family protein -
JNN35_RS00325 74117..74602 - 486 WP_001411192.1 antirestriction protein -
JNN35_RS00330 74694..75512 - 819 WP_001175173.1 DUF945 domain-containing protein -
JNN35_RS00335 75602..75835 - 234 WP_001278284.1 DUF905 family protein -
JNN35_RS00340 75841..76518 - 678 WP_001097567.1 hypothetical protein -
JNN35_RS00345 76669..77349 - 681 WP_001282911.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13965.02 Da        Isoelectric Point: 8.2830

>T188703 WP_000854775.1 NZ_CP068828:c72714-72340 [Escherichia coli]
MKTLPDTLVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T188703 NZ_CP090539:206805-207290 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13678.37 Da        Isoelectric Point: 5.4492

>AT188703 WP_001285645.1 NZ_CP068828:c73172-72804 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRADIRGRFSDADAYHLDQAFPLLMKQLELMLTNG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT188703 NZ_CP090539:206530-206817 [Salmonella enterica]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3PN67

Antitoxin

Source ID Structure
AlphaFold DB A0A426P7N5

References