Detailed information of TA system TA188695

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3717550..3718370
• Replicon: chromosome
• Accession: NZ_CP068827
• Organism: Escherichia coli strain RIVM_C030371

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A0V9MKL8
• Locus tag: JNN58_RS17770
• Protein ID: WP_001550554.1
• Coordinates: 3718113..3718370 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: JNN58_RS17765
• Protein ID: WP_001519303.1
• Coordinates: 3717550..3718101 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN58_RS17730	3713245..3714558	-	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-
JNN58_RS17735	3714570..3714848	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
JNN58_RS17740	3714845..3715966	-	1122	WP_000010833.1	M42 family metallopeptidase	-
JNN58_RS17745	3716211..3716327	-	117	Protein_3464	VOC family protein	-
JNN58_RS17750	3716365..3716625	-	261	WP_000084876.1	hypothetical protein	-
JNN58_RS17755	3716752..3717300	-	549	WP_001519301.1	hypothetical protein	-
JNN58_RS17760	3717337..3717498	-	162	WP_001519302.1	hypothetical protein	-
JNN58_RS17765	3717550..3718101	-	552	WP_001519303.1	N-acetyltransferase	Antitoxin
JNN58_RS17770	3718113..3718370	-	258	WP_001550554.1	hypothetical protein	Toxin
JNN58_RS17775	3718747..3719046	-	300	WP_001519304.1	GNAT family N-acetyltransferase	-
JNN58_RS17780	3719109..3720350	+	1242	Protein_3471	helicase YjhR	-
JNN58_RS17785	3720933..3721913	-	981	WP_001519307.1	transposase	-
JNN58_RS17790	3721978..3723084	-	1107	WP_001519308.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB / fimE / fimA / fimI / fimC	3717550..3729355	11805

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9744.33 Da
• Isoelectric Point: 11.0090

>T188695 WP_001550554.1 NZ_CP068827:c3718370-3718113 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T188695 NZ_CP090535:3723328-3723603 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT188695 WP_001519303.1 NZ_CP068827:c3718101-3717550 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT188695 NZ_CP090535:c3723593-3723171 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A0V9MKL8