188689

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2846115..2846947 Replicon chromosome
Accession NZ_CP068827
Organism Escherichia coli strain RIVM_C030371

Toxin (Protein)


Gene name yeeV Uniprot ID E3PN67
Locus tag JNN58_RS13665 Protein ID WP_000854775.1
Coordinates 2846573..2846947 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A426P7N5
Locus tag JNN58_RS13660 Protein ID WP_001285645.1
Coordinates 2846115..2846483 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN58_RS13625 2841938..2842618 + 681 WP_001282911.1 WYL domain-containing protein -
JNN58_RS13630 2842769..2843446 + 678 WP_001097567.1 hypothetical protein -
JNN58_RS13635 2843452..2843685 + 234 WP_001278284.1 DUF905 family protein -
JNN58_RS13640 2843775..2844593 + 819 WP_001175173.1 DUF945 domain-containing protein -
JNN58_RS13645 2844685..2845170 + 486 WP_000213721.1 antirestriction protein -
JNN58_RS13650 2845186..2845662 + 477 WP_001318130.1 RadC family protein -
JNN58_RS13655 2845731..2845952 + 222 WP_000692303.1 DUF987 domain-containing protein -
JNN58_RS13660 2846115..2846483 + 369 WP_001285645.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JNN58_RS13665 2846573..2846947 + 375 WP_000854775.1 TA system toxin CbtA family protein Toxin
JNN58_RS13670 2846944..2847435 + 492 WP_000976825.1 hypothetical protein -
JNN58_RS13675 2847447..2847644 + 198 WP_000772035.1 DUF957 domain-containing protein -
JNN58_RS13680 2847729..2848571 + 843 WP_001274548.1 DUF4942 domain-containing protein -
JNN58_RS13685 2848755..2848937 + 183 WP_177309578.1 hypothetical protein -
JNN58_RS13690 2849365..2850549 + 1185 WP_001172876.1 sugar efflux transporter -
JNN58_RS13695 2850660..2851583 + 924 WP_000535949.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13965.02 Da        Isoelectric Point: 8.2830

>T188689 WP_000854775.1 NZ_CP068827:2846573-2846947 [Escherichia coli]
MKTLPDTLVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T188689 NZ_CP090535:900712-901239 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13678.37 Da        Isoelectric Point: 5.4492

>AT188689 WP_001285645.1 NZ_CP068827:2846115-2846483 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRADIRGRFSDADAYHLDQAFPLLMKQLELMLTNG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT188689 NZ_CP090535:900425-900715 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3PN67

Antitoxin

Source ID Structure
AlphaFold DB A0A426P7N5

References